PMID: 3212888Nov 1, 1988Paper

Lesions in Brangus cattle with Chediak-Higashi syndrome

Veterinary Pathology
J R AyersG A Padgett

Abstract

Hair, peripheral blood leukocytes, and other tissues from two related Brangus calves with phenotypic characteristics of Chediak-Higashi syndrome were examined by light and electron microscopy. Enlarged, pleomorphic, cytoplasmic granules, morphologically compatible with lysosomes, were seen in several neutrophils, many eosinophils, renal tubular epithelial cells, and Kupffer cells. Hair shafts of the calves showed irregular distribution and clumping of melanin granules. Severe infection and a possible hemorrhagic tendency were recognized. These Brangus calves represent the third breed of cattle affected with this genetic disease.

References

Feb 1, 1972·Annals of Internal Medicine·S M Wolff
Apr 1, 1983·Nihon juigaku zasshi. The Japanese journal of veterinary science·T UmemuraC Itakura
May 1, 1981·The Journal of Heredity·D J Prieur, L L Collier
Jan 1, 1947·The Journal of Pathology and Bacteriology·H L SHEEHAN, G W STOREY

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Citations

Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Shannon Jones Hostetter
Feb 6, 2008·The Veterinary Clinics of North America. Small Animal Practice·Peter Vajdovich
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Mary K Boudreaux
Oct 26, 2002·The Journal of Veterinary Medical Science·Mitsuya ShiraishiKatsuaki Ito

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