PMID: 8950020Nov 1, 1996Paper

Lesions in the magnocellular preoptic nucleus decrease olfactory investigation in rats

Behavioural Brain Research
A G Paolini, J S McKenzie

Abstract

The nuclear complex of the horizontal limb of the diagonal band and the magnocellular preoptic nucleus, components of the basal forebrain magnocellular system affected in Alzheimer-type dementia, supply centrifugal innervation to the olfactory bulb. The lateral magnocellular preoptic nucleus provides significant GABAergic input. Since its stimulation may facilitate olfactory bulb mitral cells, we have investigated the effect of sub-total electrolytic lesions in this nucleus on performance in a simple test of olfactory investigation and its habituation. Two groups of rats used with lesions which occupied restricted volumes, approximately 30 and 15% of the magnocellular preoptic nucleus. Behaviorally, there was interference with olfactory investigation, with increased investigation latency and decreased investigation times, the group with larger lesions at 6 and 16 days after operation. There was no significant effect of the smaller lesions. No effects on patterns of olfactory habituation or discrimination were seen. The impairment of olfactory investigation could not be explained by interruption of medial forebrain bundle fibres traversing the nucleus. It is suggested that bilateral partial destruction of magnocellular preoptic ...Continue Reading

References

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Citations

Apr 24, 2010·Brain : a Journal of Neurology·Nicolaas I BohnenKirk A Frey
Dec 16, 2005·Chemical Senses·John W Scott
Aug 4, 2005·Learning & Memory·Karin RichterMario Engelmann
Feb 9, 2005·The Journal of Comparative Neurology·Heike EndepolsWolfgang Walkowiak
Jul 11, 2000·Nature Genetics·J N FergusonJ T Winslow
Aug 15, 2017·Journal of Neural Transmission·Raffaele NardoneLuca Sebastianelli

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