Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Elena-Dana BaraboiDenis Richard

Abstract

The mechanism and route whereby glucagon-like peptide 1 (GLP-1) receptor agonists, such as GLP-1 and exendin-4 (Ex-4), access the central nervous system (CNS) to exert their metabolic effects have yet to be clarified. The primary objective of the present study was to investigate the potential role of two circumventricular organs (CVOs), the area postrema (AP) and the subfornical organ (SFO), in mediating the metabolic and CNS-stimulating effects of Ex-4. We demonstrated that electrolytic ablation of the AP, SFO, or AP + SFO does not acutely prevent the anorectic effects of Ex-4. AP + SFO lesion chronically decreased food intake and body weight and also modulated the effect of Ex-4 on the neuronal activation of brain structures involved in the hypothalamic-pituitary-adrenal axis and glucose metabolism. The results of the study also showed that CVO lesions blunted Ex-4-induced expression of c-fos mRNA (a widely used neuronal activity marker) in 1) limbic structures (bed nucleus of the stria terminalis and central amygdala), 2) hypothalamus (paraventricular hypothalamic nucleus, supraoptic nucleus, and arcuate nucleus), and 3) hindbrain (lateral and lateral-external parabrachial nucleus, medial nucleus of the solitary tract, and v...Continue Reading

References

Mar 1, 1990·The American Journal of Physiology·D C Simonson, R A DeFronzo
Feb 1, 1989·The American Journal of Physiology·G L Edwards, R C Ritter
Apr 15, 1985·The Journal of Comparative Neurology·R E Shapiro, R R Miselis
Jun 1, 1984·Physiology & Behavior·R C Ritter, G L Edwards
Apr 1, 1983·The American Journal of Physiology·T M Hyde, R R Miselis
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·P C EvenA Pele
Jul 1, 1993·Frontiers in Neuroendocrinology·G E HoffmanJ G Verbalis
Apr 1, 1993·Digestive Diseases and Sciences·A WettergrenJ J Holst
Oct 1, 1996·The American Journal of Physiology·M Tang-ChristensenS P Sheikh
Dec 31, 1997·The American Journal of Physiology·Y TakahashiQ J Pittman
Mar 21, 1998·The Journal of Clinical Investigation·A FlintJ J Holst
Dec 22, 1999·Endocrine Reviews·T J Kieffer, J F Habener
Apr 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FlintA Astrup
Feb 24, 2001·Endocrine Research·L J MugliaJ A Majzoub
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Hans-Rudolf Berthoud
Sep 5, 2003·Physiology & Behavior·Stuart A McCaugheyMichael G Tordoff
May 10, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alfred AzizFrance Cho

❮ Previous
Next ❯

Citations

Jan 9, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J J Holst
Aug 7, 2012·Diabetes, Obesity & Metabolism·T A Lutz
Sep 10, 2014·The Journal of Clinical Investigation·Anna SecherLotte Bjerre Knudsen
Jan 13, 2011·Current Medical Research and Opinion·Jens Juul HolstEsther Nathanson
Mar 5, 2011·Physiology & Behavior·Mukesh PunjabiGustavo Pacheco-López
Mar 17, 2010·Physiology & Behavior·Matthew R HayesScott E Kanoski
Jun 16, 2011·British Journal of Pharmacology·Jonathan D RothDavid G Parkes
Dec 15, 2012·The Journal of Comparative Neurology·Guibao GuJoseph S Heilig
May 9, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Timo D MüllerMatthias H Tschöp
Aug 1, 2015·The Journal of Physiology·Charles Colin Thomas Hindmarch, Alastair V Ferguson
Aug 28, 2014·The Journal of Comparative Neurology·Alexandre CaronDenis Richard
Jun 8, 2011·Nature Reviews. Endocrinology·Jason G BarreraRandy J Seeley
Jan 24, 2019·Journal of Neuroendocrinology·Michael J McKinleyBrian J Oldfield
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elena-Dana BaraboiDenis Richard
Jan 1, 2014·Expert Review of Endocrinology & Metabolism·Nicolai Jacob Wewer AlbrechtsenJens Juul Holst
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stefan Trapp, Simon C Cork
Mar 27, 2021·Nature Metabolism·Mette Q LudwigTune H Pers
Mar 31, 2018·Biochemical and Biophysical Research Communications·Parmila KumariToshihiko Yada
Sep 15, 2021·British Journal of Pharmacology·Anita KabahiziKevin W Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.