PMID: 2117988Jun 4, 1990Paper

Lesions of the dopaminergic nigrostriatal system in neonatal rats: effects on the electrophysiological activity of striatal neurons recorded during adulthood

Brain Research
S P OnnT W Berger

Abstract

The spontaneous activity of single striatal neurons was recorded extracellularly from 3-4-month-old adult rats that had been given dopamine (DA)-depleting brain lesions 3 days after birth. Behavioral observations made prior to recording indicated no gross sensorimotor deficits, yet subsequent biochemical analyses revealed that animals had sustained near-total DA depletions (greater than 99%). Electrophysiological results showed that the firing rates of type II striatal cells were greatly increased relative to control levels. This finding contrasts sharply with the effects of DA-depleting brain lesions given to adult animals, in which similarly high levels of striatal cell activity are invariably associated with akinesia.

References

Nov 1, 1977·Brain Research Bulletin·C R Almli, R S Fisher
Nov 1, 1974·Journal of Comparative and Physiological Psychology·J F MarshallP Teitelbaum
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Feb 1, 1984·Behavioral Neuroscience·J P BrunoE M Stricker

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