Lesions to Lateral Prefrontal Cortex Impair Lexical Interference Control in Word Production

Frontiers in Human Neuroscience
Vitória PiaiDiane Swick

Abstract

Speaking is an action that requires control, for example, to prevent interference from distracting or competing information present in the speaker's environment. Control over task performance is thought to depend on the lateral prefrontal cortex (PFC). However, the neuroimaging literature does not show a consistent relation between left PFC and interference control in word production. Here, we examined the role of left PFC in interference control in word production by testing six patients with lesions to left PFC (centered around the ventrolateral PFC) on a control-demanding task. Patients and age-matched controls named pictures presented along with distractor words, inducing within-trial interference effects. We varied the degree of competing information from distractors to increase the need for interference control. Distractors were semantically related, phonologically related, unrelated to the picture name, or neutral (XXX). Both groups showed lexical interference (slower responses with unrelated than neutral distractors), reflecting naming difficulty in the presence of competing linguistic information. Relative to controls, all six left PFC patients had larger lexical interference effects. By contrast, patients did not show...Continue Reading

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Citations

May 10, 2017·Psychonomic Bulletin & Review·Vitória Piai, Robert T Knight
Jun 6, 2018·Cognitive Neuropsychology·Nazbanou Nozari, Christopher R Hepner
Jun 21, 2019·Experimental Aging Research·Eve HigbyLoraine K Obler
Apr 15, 2020·Journal of Cognitive Neuroscience·Vitória PiaiSrikantan S Nagarajan
May 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Stephanie K RièsRobert T Knight
Feb 24, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Yasmeen Faroqi-Shah, Megan Gehman
Mar 20, 2018·Cognition·Michael Freund, Nazbanou Nozari

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