Lespedeza davurica (Lax.) Schindl. extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

BioMed Research International
Bhesh Raj Sharma, Dong Young Rhyu

Abstract

Lespedeza has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of Lespedeza davurica (LD) on cytokine-induced β-cell damage and streptozotocin- (STZ-) induced diabetes. RINm5F cells were treated with interleukin- (IL-) 1β and interferon- (IFN-) γ to induce pancreatic β-cell damage. The exposure of LD extract significantly decreased cell death, nitric oxide (NO) production, nitric oxide synthase (iNOS) expression, and nucleus factor-kappa B (NF-κB) p65 activation. Antidiabetic effects of LD extract were observed by oral glucose tolerance test (OGTT) in normal rats and by checking the biochemical, physiological, and histopathological parameters in STZ-induced diabetic rats. In OGTT, glucose clearance levels improved by oral treatment of LD extract. The water intake, urine volume, blood glucose, and serum TG, TC, TBARS, and DPP-IV levels were significantly decreased, and liver glycogen content was significantly increased by treatment of LD extract (250 mg/kg BW) in STZ-induced diabetic rats. Also, insulin immunoreactivity of the pancreases was increased in LD extract administrated rats compared with diabetic control rats. These...Continue Reading

References

Nov 1, 1990·International Journal of Radiation Biology·R Varshney, R K Kale
Nov 24, 1994·The New England Journal of Medicine·M A Atkinson, N K Maclaren
May 6, 2004·Annals of the New York Academy of Sciences·Yoshitaka Kajimoto, Hideaki Kaneto
Mar 23, 2005·Regulatory Peptides·Christopher H S McIntoshRaymond Pederson
Jul 26, 2006·World Journal of Gastroenterology : WJG·Kang-Beom KwonByung-Hyun Park
Oct 19, 2007·Journal of Asian Natural Products Research·Fei DengJin-Sheng Zhang
Apr 9, 2009·Nature Reviews. Endocrinology·Décio L EizirikFernanda Ortis
Jun 16, 2010·Critical Reviews in Clinical Laboratory Sciences·Thomas R CsorbaMorley D Hollenberg
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
Mar 20, 2013·BioMed Research International·Daye ChengYunhui Li
Jun 27, 2014·BioMed Research International·Khalid GhazanfarMudasir A Tantry

❮ Previous
Next ❯

Citations

Apr 30, 2016·International Journal of Environmental Research and Public Health·Pedro H Miranda-OsorioJuan C Díaz-Zagoya

❮ Previous
Next ❯

Methods Mentioned

BETA
Reverse Transcription Polymerase Chain Reaction
PCR

Software Mentioned

SPSS
Visionworks

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.