Less cholesterol means better tumor killing for cytotoxic T9 cells.

The Journal of Experimental Medicine
Brad Griesenauer, Sophie Paczesny

Abstract

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

References

Sep 20, 2007·Journal of Cell Science·Chun-Lin ChenJung San Huang
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jul 10, 2012·Nature Medicine·Rahul PurwarThomas S Kupper
Oct 16, 2012·The Journal of Clinical Investigation·Yong LuQing Yi
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yong LuQing Yi
Oct 16, 2014·The New England Journal of Medicine·Shannon L MaudeStephan A Grupp
Jan 22, 2015·Oncology Reports·Abdullah K Altwairgi
Oct 9, 2016·The New England Journal of Medicine·Alexander M M EggermontAlessandro Testori
Jul 6, 2017·Nature·Patrick A OttCatherine J Wu
Oct 19, 2017·The Journal of Experimental Medicine·Abdulraouf RamadanSophie Paczesny
Dec 12, 2017·The New England Journal of Medicine·Sattva S NeelapuWilliam Y Go
May 11, 2018·The Journal of Experimental Medicine·Xingzhe MaQing Yi

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BETA
transgenic

Software Mentioned

Ingenuity Pathway Analysis

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