Less developed corpus callosum in dyslexic subjects--a structural MRI study

Neuropsychologia
Kerstin von PlessenKenneth Hugdahl

Abstract

Based on previous studies and due to the characteristics of dyslexia as an auditory phonological decoding disorder, we predicted that the shape of the posterior corpus callosum (CC) would differ between dyslexic and control subjects. Twenty right-handed boys with developmental dyslexia were selected from a carefully screened general population sample (mean age 11 years) and compared to a matched control group. The CC contour was manually traced on the aligned midsagittal MR slice and total callosal area and its subregions were compared between the groups. A statistical shape analysis and subsequent CC classification was performed using a recently developed shape model method. The shape analysis revealed shorter CC shape in the dyslexic group, localised in the posterior midbody/isthmus region. This region contains interhemispheric fibers from primary and secondary auditory cortices. A shape length difference larger than a fixed threshold in the posterior midbody region could correctly discriminate between control and dyslexic subject in 78% of the cases, where a dyslexic CC was shorter in this region than a control CC. However, there were no significant group differences with respect to overall CC area or subregions. A clear sha...Continue Reading

References

Dec 11, 1992·Brain Research·F AboitizE Zaidel
Aug 1, 1990·Brain and Language·C M TempleO O Vilarroya
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·M C de LacosteE D Ross
Apr 1, 1972·Scientific American·N Geschwind
Jul 12, 1968·Science·N Geschwind, W Levitsky
Nov 1, 1967·The Quarterly Journal of Experimental Psychology·M Annett
Jun 25, 1982·Science·C DeLacoste-Utamsing, R L Holloway
Oct 20, 1994·Behavioural Brain Research·C NjiokiktjienJ Vaal
Sep 1, 1993·Neuropsychologia·B C Summerfield, P T Michie
Jan 1, 1996·Journal of Computer Assisted Tomography·C DavatzikosR N Bryan
Jun 1, 1996·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·L H MooreJ C Zvi
Apr 2, 1999·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P A Filipek
Jun 1, 2000·European Neurology·F RobichonM Habib
Sep 6, 2000·Medical Image Analysis·A LundervoldA M Fenstad

❮ Previous
Next ❯

Citations

Mar 27, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Brent R CollettMatthew L Speltz
Jul 5, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jascha RüsselerThomas F Münte
Jan 28, 2004·Neuropsychology·Deny MenghiniStefano Vicari
Nov 25, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Jascha RüsselerClaudia Quaiser-Pohl
Oct 28, 2009·Journal of Clinical and Experimental Neuropsychology·Natacha DeroostEric Soetens
Sep 18, 2010·Cerebral Cortex·René WesterhausenKenneth Hugdahl
Jan 19, 2013·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Mohammad Reza MohammadiMohammad Jafar Golalipour
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Robert F DoughertyBrian A Wandell
Jul 30, 2011·AJNR. American Journal of Neuroradiology·C GarelH Ducou le Pointe
Jun 8, 2011·Neuroscience Letters·G BersaniG Gualdi
Aug 25, 2006·Journal of Anatomy·Mojtaba ZareiPaul M Matthews
Nov 17, 2005·Nature Reviews. Neuroscience·Giorgio M Innocenti, David J Price
Sep 27, 2005·NeuroImage·Maria G KnyazevaPhilippe Maeder
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marjorie A GarveyUlf Ziemann
Jun 21, 2005·Neuropsychologia·Alan BeatonAmanda Peggie
Aug 9, 2007·Developmental Science·Dorothy V M BishopWaldemar von Suchodoletz
Jun 1, 2010·Translational Neuroscience·Manuel F CasanovaAndrew E Switala
Oct 14, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Monica DharMonika Althaus
Dec 17, 2014·Pediatric Neurology·Chaw-Liang ChangNan-Chang Chiu
Jun 12, 2016·NeuroImage·René WesterhausenKristine B Walhovd
Feb 24, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·N A TaroyanA J Fawcett
Aug 9, 2016·Research in Developmental Disabilities·John R Kershner
Jul 24, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mark Eckert
Feb 28, 2017·Human Brain Mapping·Xiaochen SunGaolang Gong
Jun 23, 2006·Arquivos de neuro-psiquiatria·Armando Freitas da RochaCarla Cristina M Oliveira
Feb 16, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Ahmed ElnakibAyman El-Baz
Jun 25, 2005·Brain : a Journal of Neurology·G SilaniE Paulesu
Jun 2, 2018·Neurology Research International·Hilda Nouri HosseiniMohammad Jafar Golalipour

❮ Previous
Next ❯

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