PMID: 9194584May 1, 1997Paper

Less expression of cyclin E in cutaneous squamous cell carcinomas than in benign and premalignant keratinocytic lesions

Journal of Cutaneous Pathology
T BitoM Ichihashi

Abstract

In a previous study, we showed that overexpression of cyclin D, a G1 cyclin, is frequently associated with keratinocyte carcinogenesis as an early event. Another G1 cyclin, cyclin E, was recently suggested to be a prognostic marker for breast cancer. In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Positive cells were seen rarely in normal epidermis, in 9 of 20 cases of SK, in 5 of 6 cases of KA, in 9 of 13 cases of AK and in all 27 cases of BD. Some of the cases of AK and BD had positive cells in the superficial epidermis, where atypicality is less obvious. In contrast, positive cells were seen in 4 of 25 cases of SCC and none of 15 cases of BCC. These results suggest that expression of cyclin E plays a role in the formation of benign and premalignant keratinocytic tumors, whereas down-regulation of cyclin E expression may be involved in carcinogenesis in human keratinocytes.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·A DuttaS Lester
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Citations

May 29, 2002·Molecular Pathology : MP·C SimoneG Guanti
Jan 17, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Li-nian HuangWei Jia
Sep 10, 2015·Journal of Cutaneous Pathology·Dimitrije BrasanacEmilija Manojlovic-Gacic
Feb 14, 2004·The Australasian Journal of Dermatology·John P Arlette, Martin J Trotter
Sep 28, 1999·Nature·C H SpruckS I Reed
May 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Donnellan, R Chetty
Aug 21, 2013·Cancer Research·Mylinh T DuongKhandan Keyomarsi
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kamal E Bani-HaniHanan N Karam

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