Less invasive surfactant administration and complications of preterm birth

Scientific Reports
Christoph HärtelWolfgang Göpel

Abstract

In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate whether less invasive surfactant administration (LISA) strategy is associated with complications of preterm birth. Within the observational period n = 7533 very-low-birth-weight infants (VLBWI) with gestational age 22 0/7 to 28 6/7 weeks were enrolled in GNN; n = 1214 VLBWI never received surfactant, n = 2624 VLBWI were treated according to LISA procedure, n = 3695 VLBWI had surfactant via endotracheal tube (ETT). LISA was associated with a reduced risk for adverse outcome measures including mortality [odds ratio (OR) 0.66 (95% CI: 0.51-0.84), p < 0.001] bronchopulmonary dysplasia [BPD; OR 0.55 (95% CI: 0.49-0.62), p < 0.001], intracerebral hemorrhage (ICH) grade II-IV [OR 0.55 (95% CI: 0.48-0.64), p < 0.001] and retinopathy of prematurity [ROP; OR 0.62 (95% CI: 0.45-0.85), p < 0.001]. Notably, LISA was associated with an increased risk for focal intestinal perforation [FIP; OR 1.49 (95% CI: 1.14-1.95), p = 0.002]. The differences in FIP rates were primarily observed in VLBWI born <26 weeks (LISA: 10.0 vs. ETT: 7.4%, p = 0.029). Our observational data confirm that LISA is associated with improved outcome. In infants <26 weeks we noted an increased...Continue Reading

References

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Dec 11, 2008·American Journal of Perinatology·Phillip V Gordon, Joshua T Attridge
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Jun 2, 2014·The Journal of Pediatrics·Christoph HärtelUNKNOWN German Neonatal Network
Sep 30, 2016·European Journal of Pediatrics·Vincent RigoIsabelle Broux

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Citations

Mar 1, 2019·Expert Review of Respiratory Medicine·Frans J WaltherAlan J Waring
Dec 14, 2019·Pediatric Pulmonology·Anders NordValeria Perez-de-Sa
Jul 13, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Egbert HertingWolfgang Göpel
Feb 19, 2020·Current Opinion in Pediatrics·Egbert HertingWolfgang Göpel
Feb 14, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Manuel Sánchez LunaCristina Ramos Navarro
Jul 15, 2020·Seminars in Immunopathology·Alexander HumbergUNKNOWN German Neonatal Network, German Center for Lung Research and Priming Immunity at the beginning of life (PRIMAL) Consortium
Jan 17, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ioannis BellosAakash Pandita
Jan 26, 2021·Health Science Reports·Johanes Edy SiswantoPieter J J Sauer
Mar 2, 2021·Journal of Neonatal-perinatal Medicine·T QuelizM J Corrigan
Aug 12, 2021·Pediatric Pulmonology·Usha Devi, Aakash Pandita
Sep 25, 2021·American Journal of Perinatology·Soume BhattacharyaOrlando da Silva
Oct 22, 2021·BMJ : British Medical Journal·Margaret GilfillanVineet Bhandari
Nov 5, 2021·Journal of Clinical Pharmacy and Therapeutics·Joseph V PergolizziRobert B Raffa
Feb 1, 2022·Acta Paediatrica·Clyde J WrightNicolas A Bamat

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Methods Mentioned

BETA
LISA
SGA
X-ray

Software Mentioned

SPSS

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