Less irritative action of wine and Japanese sake in rat stomachs: a comparative study with ethanol

Digestive Diseases and Sciences
A NakagiriK Takeuchi

Abstract

The ingestion of alcohol, especially in excess, causes acute gastric lesions and gastritis in humans, yet the mucosal irritative action of alcoholic beverages remains largely unknown. We examined the mucosal irritative action of whiskey, wine and Japanese sake in the rat stomach both ex vivo and in vitro, in comparison with ethanol. Under urethane anesthesia, a rat stomach was mounted in an ex vivo chamber, then superfused with saline, and the transmucosal potential difference (PD) was measured. After the basal PD had stabilized, the mucosa was exposed for 30 min to 2 ml of 15% ethanol, whiskey (containing 15% ethanol), white wine, or Japanese sake (the ethanol concentration of the latter two is 12-15%). In the in vitro study, rat epithelial cells (RGM1) were treated with the alcoholic beverages for 5 min, and the cell viability was determined with crystal violet. Ethanol or whiskey applied to the chamber caused a decrease in PD, while wine or Japanese sake did not. Histologically, surface epithelial damage was observed after exposure to both ethanol and whiskey, yet no damage was induced by white wine and Japanese sake. Likewise, both ethanol and whiskey markedly reduced the viability of RGM1 cells after 5 min of incubation, w...Continue Reading

References

Jun 1, 1988·Gastroenterology·L Laine, W M Weinstein
Dec 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·H W Davenport
Jul 1, 1983·The American Journal of Physiology·D L Stetson, P R Steinmetz
Nov 1, 1983·Digestive Diseases and Sciences·K Takeuchi, S Okabe
Jan 1, 1994·Journal of Gastroenterology and Hepatology·C H ChoX L Tang
Feb 1, 1997·Journal of Ethnopharmacology·A T Mobarok Ali, O A al-Swayeh
Apr 23, 2002·Alimentary Pharmacology & Therapeutics·K MatsunoS Okabe
Jun 5, 2002·Alcoholism, Clinical and Experimental Research·Wataru FujiiKohtaro Taniyama
Oct 17, 2002·The Journal of Physiology·Philip A Helliwell, George L Kellett
Dec 18, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Kamel GharzouliSeddik Khennouf
Sep 10, 2003·Biochemical Pharmacology·Shinichi KatoKoji Takeuchi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.