Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls

Journal of Applied Physiology
C EkmanO Hansson

Abstract

Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared with FH-. Sixteen FH+ and 19 FH- insulin-sensitive men similar in age, peak oxygen consumption (V̇o2 peak), and body mass index completed an exercise intervention with heart rate monitored during exercise for 7 mo. Before and after the exercise intervention, the participants underwent a physical examination and tests for glucose tolerance and exercise capacity, and muscle biopsies were taken for expression analysis. The participants attended, on average, 39 training sessions during the intervention and spent 18.8 MJ on exercise. V̇o2 peak/kg increased by 14%, and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH+ group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH- groups separately. Exercise volume had a significant effect on V̇o2 peak, weight, and waist circumference in the FH- group, but not in the FH+ group. After exercise, expressio...Continue Reading

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Citations

Apr 5, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Peter Plomgaard, Cora Weigert
Jun 22, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Henrik WagnerThomas Gustafsson
Feb 19, 2016·Physiological Reports·Louise H NaylorDaniel J Green
May 26, 2016·MMW Fortschritte der Medizin·P Schwarz
May 29, 2019·The Journal of Clinical Endocrinology and Metabolism·Rugivan SabaratnamKurt Højlund
Mar 1, 2021·BMC Endocrine Disorders·Hemang M ParikhOla Hansson

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