Lesser-Known Molecules in Ovarian Carcinogenesis

BioMed Research International
Ludmila LozneanuIrina-Draga Căruntu

Abstract

Currently, the deciphering of the signaling pathways brings about new advances in the understanding of the pathogenic mechanism of ovarian carcinogenesis, which is based on the interaction of several molecules with different biochemical structure that, consequently, intervene in cell metabolism, through their role as regulators in proliferation, differentiation, and cell death. Given that the ensemble of biomarkers in OC includes more than 50 molecules the interest of the researchers focuses on the possible validation of each one's potential as prognosis markers and/or therapeutic targets. Within this framework, this review presents three protein molecules: ALCAM, c-FLIP, and caveolin, motivated by the perspectives provided through the current limited knowledge on their role in ovarian carcinogenesis and on their potential as prognosis factors. Their structural stability, once altered, triggers the initiation of the sequences characteristic for ovarian carcinogenesis, through their role as modulators for several signaling pathways, contributing to the disruption of cellular junctions, disturbance of pro-/antiapoptotic equilibrium, and alteration of transmission of the signals specific for the molecular pathways. For each molecu...Continue Reading

References

Jul 10, 1997·Nature·M IrmlerJ Tschopp
Mar 10, 2001·The American Journal of Pathology·K WiechenU Schneider
Apr 18, 2001·The Journal of Biological Chemistry·L C van KempenG W Swart
Apr 20, 2001·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·A HernandezB M Evers
Aug 21, 2001·The Journal of Investigative Dermatology·R R BullaniL E French
Sep 12, 2001·Advanced Drug Delivery Reviews·J CouetM C Drolet
Mar 9, 2002·Molecular and Cellular Biology·Babak RazaniMichael P Lisanti
Apr 30, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sug Hyung LeeNam Jin Yoo
Jul 11, 2003·World Journal of Gastroenterology : WJG·Yong-Bin DingLi Yang
Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hiroshi OkanoTakeshi Nakano
Jul 30, 2003·Expert Opinion on Therapeutic Targets·Olivier Micheau
Aug 2, 2003·Nature Reviews. Cancer·Lucy A Carver, Jan E Schnitzer
Nov 26, 2003·Clinical Science·Xiao-Dong ZhouHong-Gang Yu
Mar 3, 2004·Molecular Interventions·Harald Wajant
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Delia MezzanzanicaSilvana Canevari
Aug 21, 2004·Breast Cancer Research : BCR·Judy A KingWen G Jiang
Oct 29, 2004·Journal of Clinical Pathology·W WeichertG Kristiansen
Feb 5, 2005·American Journal of Physiology. Cell Physiology·Terence M Williams, Michael P Lisanti
Mar 10, 2005·British Journal of Haematology·Marie-Blanche Valnet-RabierThierry Fest
May 3, 2005·Gynecologic Oncology·Peter HorakMichael Krainer
Jul 8, 2005·Nature·Lucas Pelkmans, Marino Zerial
Sep 2, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W I SilvaI K Salgado-Villanueva
Oct 1, 2005·Leukemia & Lymphoma·Carmen BergomPeter J Newman
Jun 29, 2006·International Journal of Cancer. Journal International Du Cancer·Daniela AldoviniMattia Barbareschi
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna IbáñezFrancisco Lozano
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfons S K de HoogeArjan C Lankester
Feb 15, 2007·The Prostate·Jose A KaramShahrokh F Shariat
Mar 30, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chengguo DengYing Yu
Jun 15, 2007·Surgery·Christina L RolandCarlton C Barnett

❮ Previous
Next ❯

Citations

Mar 31, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiahui LiKui Jiang
Jan 9, 2021·Frontiers in Oncology·Jill AlldredgeFarah Rahmatpanah

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination

Related Concepts

Related Feeds

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
Elena CojocaruMihai Danciu
Postepy biochemii
Weronika WronowskaElzbieta Katarzyna Jagusztyn-Krynicka
© 2021 Meta ULC. All rights reserved