Lessons from experimental Mycobacterium tuberculosis infections

Microbes and Infection
JoAnne L Flynn

Abstract

Mycobacterium tuberculosis is the cause of enormous human morbidity and mortality each year. Although this bacterium can infect and cause disease in many animals, humans are the natural host. For the purposes of studying the pathogenesis of M. tuberculosis, as well as the protective and immunopathologic host responses against this pathogen, suitable animal models must be used. However, modeling the human infection and disease in animals can be difficult, and interpreting the data from animal models must be done carefully. In this paper, the animal models of tuberculosis are discussed, as well as the limitations and advantages of various models. In particular, the lessons we have learned about tuberculosis from the mouse models are highlighted. The careful and thoughtful use of animal models is essential to furthering our understanding of M. tuberculosis, and this knowledge will enhance the discovery of improved treatment and prevention strategies.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L FlynnB R Bloom
Jan 1, 1988·European Journal of Immunology·G De LiberoS H Kaufmann
Sep 5, 1968·Annals of the New York Academy of Sciences·R C Good
Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Apr 1, 1996·Infection and Immunity·Y LinP F Barnes
Nov 1, 1996·Infection and Immunity·P J ConverseM L Pitt
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E R RhoadesI M Orme
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·L TsenovaG Kaplan
Jul 27, 1999·Nature·D B LowrieC L Silva
Aug 24, 1999·Infection and Immunity·C A ScangaJ L Flynn
Apr 5, 2001·Trends in Molecular Medicine·D N McMurray
Jun 13, 2001·Infection and Immunity·J L Flynn, J Chan
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·W PetersJ D Ernst
Nov 14, 2001·Infection and Immunity·D M BouleyL Ramakrishnan
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C HölscherF Brombacher
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea M CooperIan M Orme
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yufei WangThomas Lehner
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanne TurnerAndrea M Cooper
Aug 12, 2003·AIDS Research and Human Retroviruses·Hassan SafiPeter F Barnes
Oct 18, 2003·Cytokine & Growth Factor Reviews·Holly M Scott AlgoodJoAnne L Flynn
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siobhán C Cowley, Karen L Elkins

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Citations

Feb 26, 2010·Pharmaceutical Research·Pavan MuttilAnthony J Hickey
Apr 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Frank HeutsMartin E Rottenberg
Jul 27, 2011·The Journal of Experimental Medicine·Jacob E KohlmeierDavid L Woodland
Oct 30, 2008·The Journal of Infectious Diseases·Nicholas A BeSanjay K Jain
Nov 26, 2009·The Journal of Infectious Diseases·Subash BabuThomas B Nutman
Nov 29, 2013·Science Translational Medicine·Robert L Modlin, Barry R Bloom
Jun 2, 2011·Antimicrobial Agents and Chemotherapy·Damian Guang FooMaxime Hervé
Nov 8, 2008·Molekuliarnaia biologiia·A S Apt, T K Kondrat'eva
May 12, 2007·Annual Review of Genomics and Human Genetics·A FortinP Gros
Aug 3, 2007·The Journal of Clinical Investigation·W Henry Boom
Apr 3, 2008·The Journal of Clinical Investigation·Douglas B YoungClifton E Barry
Oct 19, 2010·BMC Infectious Diseases·Michael HawkesKevin C Kain
Mar 11, 2011·PloS One·Ralph CarvalhoHerman P Spaink
May 22, 2013·PloS One·Veronica E CalderonJanice J Endsley
Sep 24, 2013·Human Molecular Genetics·Emile R ChimusaEileen G Hoal

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