Lessons from the first year of the WAIVE study investigating the protective effect of influenza vaccine against laboratory-confirmed influenza in hospitalised children aged 6-59 months.

Influenza and Other Respiratory Viruses
Gabriela A DixonWAIVE study team

Abstract

Influenza is major cause of paediatric hospitalisation. Influenza vaccine was offered to all children aged 6-59 months resident in Western Australia in 2008, and we wished to evaluate the effectiveness of this immunisation programme. To assess the practicalities of a nested matched case-control design to estimate the protective effect of inactivated influenza vaccination in hospitalised children aged 6-59 months. Cases were hospitalised children with laboratory-confirmed influenza, while matched controls were recruited from children admitted for an acute non-respiratory illness. We estimated influenza vaccine effectiveness (VE) against influenza as 1--the adjusted odds ratio from multivariate logistic regression. The 2008 influenza season was characterised by a late peak and a predominance of influenza virus B. We recruited 26 hospitalised patients with laboratory-confirmed influenza and 50 matched controls. The proportion of cases who were fully vaccinated was 7% versus 30% of controls giving an adjusted VE of 83% (95% CI--54 to 98). Recruiting sufficient controls was problematic and in the future, we will select controls hospitalised for an influenza-like-illness but influenza negative by laboratory PCR testing. The VE estima...Continue Reading

References

Sep 7, 2006·Journal of Clinical Microbiology·Nicole L ZitterkopfThomas F Smith
Apr 4, 2007·International Journal of Epidemiology·Evan W OrensteinWalter A Orenstein
May 31, 2007·Journal of Paediatrics and Child Health·Hannah MooreDeborah Lehmann
Dec 29, 2007·Journal of Lower Genital Tract Disease·Philip E CastleMark Schiffman
Dec 18, 2008·The Journal of Infectious Diseases·Edward A BelongiaUNKNOWN Marshfield Influenza Study Group
Jan 1, 2008·Journal of Pain & Palliative Care Pharmacotherapy· National Quality Measures Clearinghouse, Agency For Healthcare Research And Quality
Jan 1, 2008·Annals of Vascular Diseases·Takehisa IwaiMakoto Umeda

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Citations

Mar 1, 2013·Journal of the Pediatric Infectious Diseases Society·Nicholas T ConwayUNKNOWN Western Australia Influenza Vaccine Effectiveness (WAIVE) Team
Oct 3, 2012·Australian and New Zealand Journal of Public Health·Donna B MakPaul V Effler
Aug 6, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Christopher C BlythAllen C Cheng
Aug 24, 2018·Influenza and Other Respiratory Viruses·Gabriela A WillisUNKNOWN WAIVE Study Team
Aug 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher C BlythUNKNOWN Influenza Complications Alert Network (FluCAN) Collaboration
Jul 7, 2011·The Medical Journal of Australia·Christopher C BlythPeter C Richmond
Mar 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicki L BoddingtonRichard G Pebody

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Software Mentioned

WAIVE
SAS

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