Lessons from the Fukushima Daiichi nuclear power plant accident -from a research perspective.

Annals of the ICRP
Satoshi Tashiro

Abstract

Since the accident at Fukushima Daiichi nuclear power plant, there has been a focus on the impact of low-dose radiation exposure due to nuclear disasters and radiology on human bodies. In order to study very low levels of impact on the human body from low-dose radiation exposure, a system with high detection sensitivity is needed. Until now, the most well-established biological radiation effect detection system in the field of emergency radiation medicine has been chromosomal analysis. However, chromosomal analysis requires advanced skills, and it is necessary to perform chromosomal analysis of a large number of cells in order to detect slight effects on the human body due to low-dose radiation exposure. Therefore, in order to study the effects of low-dose radiation exposure on the human body, it is necessary to develop high-throughput chromosome analysis technology. We have established the PNA-FISH method, which is a fluorescence in-situ hybridisation method using a PNA probe, as a high-throughput chromosome analysis technique. Using this method, the detection of dicentrics and ring chromosomes has become very efficient. Using this technology, chromosomal analysis was performed on peripheral blood before and after computed tom...Continue Reading

References

Feb 6, 2004·Seminars in Cancer Biology·Alison M JohnRose Ann Padua
Sep 25, 2007·Annual Review of Genomics and Human Genetics·Peter J McKinnon, Keith W Caldecott
Sep 13, 2011·Nature·Kenichi YoshidaSeishi Ogawa
Apr 19, 2012·Radiation Research·Lin ShiSatoshi Tashiro
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall
Aug 8, 2015·Lancet·Kenji KamiyaRichard Wakeford
Oct 8, 2015·Annual Review of Physiology·Anna UrygaMartin Bennett
Nov 23, 2017·Journal of the National Cancer Institute·Alexey A EfanovYuri E Nikiforov
Mar 11, 2020·Radiology·Hiroaki SakaneSatoshi Tashiro

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