PMID: 18406764Nov 1, 1996Paper

Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus

Trends in Endocrinology and Metabolism : TEM
M E Patti, C R Kahn

Abstract

The application of transgenic techniques to alter gene expression in vivo has provided new models to evaluate the role of specific genes in the complex pathogenesis of noninsulin-dependent diabetes mellitus (NIDDM). In this review, we summarize methods used to create transgenic animals and highlight results from those models which have contributed to our understanding of the overall pathophysiology of NIDDM. Transgenic animal models have clearly demonstrated the requirement for normal insulin action in skeletal muscle, adipose tissue, and liver, as well as normal insulin secretion by the pancreatic beta-cell, in the maintenance of glucose homeostasis. In addition, these data confirm that isolated defects in single critical genes, including the insulin receptor, IRS-1, and glucokinase, may play a role in the development of some types of insulin resistance and NIDDM. However, it is likely that multiple additive defects, both genetic and acquired, are required to produce the full clinical syndrome typical of more common forms of NIDDM.

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Citations

Apr 27, 2001·Neuroscience and Biobehavioral Reviews·B Beck
Oct 23, 1997·Nature Medicine·S O'Rahilly
Jun 7, 2014·The Journal of Endocrinology·Rubén Marín-JuezHerman P Spaink
Mar 4, 2015·American Journal of Obstetrics and Gynecology·Luciana LassanceSylvie Hauguel-de Mouzon
Dec 17, 2014·Diabetologia·Bernard ThorensJorge Ferrer
Aug 21, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G MingroneA V Greco
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Nov 7, 1998·Nature Genetics·B B Kahn, L Rossetti
Mar 17, 2010·Endocrinology·Matthew C ErnstChristopher J Sinal
Jul 11, 2019·Diabetology & Metabolic Syndrome·Parvane SaneeiMohammad Hossein Rouhani
Sep 26, 2021·Nature Communications·Nathalie ArquierPierre Léopold

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