Lessons learned from the discovery of sodium valproate and what has this meant to future drug discovery efforts?

Expert Opinion on Drug Discovery
Slobodan M Janković, Snežana V Janković

Abstract

The discovery of the anticonvulsant properties of valproic acid and the development of valproic acid/valproate to market authorization for specific epilepsy types and syndromes, as well as their repurposing for other indications, are illustrative examples of both the strengths and weaknesses of drug development strategies. This review summarizes and interprets the development and repurposing history of valproic acid/valproate. The article is based on articles, including original studies and systematic reviews obtained from PubMed, Scopus, EBSCO, SCIndeks and Google Scholar databases. Random screening and careful observation of the experimental effects of tested substances were crucial for discovering the anticonvulsant effects of valproic acid, while rational drug design and clinical observation strategies led to repurposing valproic acid and valproate for bipolar disorder maintenance treatmentand prevention of migraine attacks. Early planning and feasibility studies of future clinical trials are essential for obtaining marketing authorization of new substances or new indications of old anticonvulsants. Significant progress has been made recently toward understanding, treatment and prevention of hepatotoxicity caused by valproi...Continue Reading

References

Apr 1, 1992·Cephalalgia : an International Journal of Headache·R Hering, A Kuritzky
Oct 1, 1988·Acta Neurologica Scandinavica·K V Sørensen
Mar 16, 1985·British Medical Journal·D M TurnbullD W Chadwick
Mar 1, 1995·Archives of Neurology·N T MathewR L Deaton
Apr 1, 1997·Cephalalgia : an International Journal of Headache·J Klapper
Jun 12, 2002·Neurology·Frederick G FreitagUNKNOWN Depakote ER Migraine Study Group
Mar 5, 2003·Acta Neurologica Scandinavica·M D PriviteraUNKNOWN EPMN 105 Study Group
Nov 26, 2003·Bipolar Disorders·Margaret HarrisDavid Healy
Apr 10, 2004·Journal of Child Neurology·James W WhelessUNKNOWN EPMN-105 Study Group
Dec 2, 2004·Journal of Affective Disorders·Mani N PavuluriPhilip G Janicak
Apr 22, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Robert L FindlingJoseph R Calabrese
Jun 17, 2006·Acta Neurologica Scandinavica. Supplementum·E Ben-MenachemF Vajda
Jun 17, 2008·British Journal of Pharmacology·M A Rogawski
Aug 19, 2008·The American Naturalist·D A Lytle
Feb 24, 2009·Journal of Child and Adolescent Psychopharmacology·Laura ReddenUNKNOWN Depakote ER Pediatric Mania Group
Sep 17, 2009·Biochemical Society Transactions·Nicole Terbach, Robin S B Williams
Sep 24, 2009·Physiology & Behavior·Annika LüttjohannGilles van Luijtelaar
Jun 19, 2010·The New England Journal of Medicine·Janneke JentinkUNKNOWN EUROCAT Antiepileptic Study Working Group
Nov 16, 2010·Seizure : the Journal of the British Epilepsy Association·Martin J Brodie
Feb 5, 2011·Seizure : the Journal of the British Epilepsy Association·Wolfgang Löscher
Jan 1, 2005·Profiles of Drug Substances, Excipients, and Related Methodology·Ibrahim A AlsarraF Belal
Sep 21, 2013·Expert Opinion on Drug Discovery·Barbara MiziakStanisław J Czuczwar
Jul 30, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Johanna HynynenJohanna Uusimaa
Aug 15, 2015·BioMed Research International·Liane Rabinowich, Oren Shibolet
Nov 26, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Jay A SalpekarMark A Riddle
Nov 26, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·John T WalkupMark A Riddle
Jul 20, 2016·Expert Opinion on Drug Metabolism & Toxicology·Sven C van DijkmanOscar Della Pasqua
Jan 10, 2017·Expert Opinion on Pharmacotherapy·Pasquale Striano, Vincenzo Belcastro
Jun 26, 2017·Current Psychiatry Reports·Peijun ChenMartha Sajatovic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

The Western Journal of Medicine
S Schneider
Indian Pediatrics
M Sharma, P Agrawal
The New England Journal of Medicine
C Garvin
The New England Journal of Medicine
J P Tift
Nihon rinsho. Japanese journal of clinical medicine
Y Kohda
© 2021 Meta ULC. All rights reserved