Lessons learned from the syndrome of oculopalatal tremor.

Journal of Computational Neuroscience
Mohamed ElkasabyAasef G Shaikh

Abstract

The syndrome of oculopalatal tremor (OPT) featuring the olivo-cerebellar hypersychrony leads to disabling pendular nystagmus and palatal myoclonus. This rare disorder provides valuable information about the motor physiology and offers insights into the mechanistic underpinning of common movement disorders. This focused review summarizes the last decade of OPT research from our laboratory and addresses three critical questions: 1) How the disease of inferior olive affects the physiology of motor learning? We discovered that our brain's ability to compensate for the impaired motor command and implement errors to correct future movements could be affected if the cerebellum is occupied in receiving and transmitting the meaningless signal. A complete failure of OPT patients to adapt to change in rapid eye movements (saccades) provided proof of this principle. 2) Whether maladaptive olivo-cerebellar circuit offers insight into the mechanistic underpinning of the common movement disorder, dystonia, characterized by abnormal twisting and turning of the body part. We discovered that the subgroup of patients who had OPT also had dystonia affecting the neck, trunk, limbs, and face. We also found that the subjects who had tremor predominan...Continue Reading

References

May 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Tyrrell, D Willshaw
Jun 1, 1969·The Journal of Physiology·D Marr
Jan 1, 1981·Acta Neuropathologica·N Goto, M Kaneko
Apr 1, 1993·Experimental Neurology·M S LeDouxJ M Ervin
Oct 30, 1995·Brain Research·M S LeDouxJ Meinzen-Derr
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·T OdergrenM Ingvar
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rodolfo R LlinasFrancisco J Urbano
Oct 26, 2005·Brain Research. Molecular Brain Research·Jianfeng Xiao, Mark S Ledoux
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Corina E AndreescuMarcel T G De Jeu
Jan 31, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stéphane ThoboisEmmanuel Broussolle
Mar 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haiyin Chen-HarrisReza Shadmehr
May 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nicolas CatzPeter Thier
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent EthierReza Shadmehr
Aug 4, 2009·Annals of the New York Academy of Sciences·Jing TianDavid S Zee
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miklos ArgyelanDavid Eidelberg
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minnan Xu-WilsonReza Shadmehr
Jan 19, 2010·Brain : a Journal of Neurology·Aasef G ShaikhLance M Optican
Feb 8, 2011·Nature Neuroscience·D Paola CalderonKamran Khodakhah
Feb 10, 2011·Neurobiology of Disease·Vladimir K NeychevH A Jinnah
Apr 13, 2011·Neuron·Martijn SchonewilleChris I De Zeeuw
Jun 17, 2011·Journal of Neurophysiology·Fabian Schnier, Markus Lappe
Sep 29, 2011·Annals of the New York Academy of Sciences·Aasef G ShaikhR John Leigh
Nov 15, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A SadnickaM J Edwards
Dec 16, 2011·The Journal of Pharmacology and Experimental Therapeutics·Xueliang FanEllen J Hess
May 18, 2012·Frontiers in Neurology·Alexander A TarnutzerDominik Straumann
Aug 2, 2012·Neurobiology of Disease·Robert S RaikeEllen J Hess
Dec 1, 2012·Experimental Neurology·C N PrudenteH A Jinnah
Feb 21, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pavel FilipMartin Bareš
Feb 27, 2013·Frontiers in Neural Circuits·Masao Ito
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aasef G ShaikhH A Jinnah
Nov 26, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Aasef G Shaikh
Apr 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Aasef G ShaikhH A Jinnah
Jan 23, 2016·Neural Networks : the Official Journal of the International Neural Network Society·Masahiko Fujita
Feb 19, 2016·Movement Disorders Clinical Practice·Aasef G ShaikhStewart A Factor
Jun 22, 2016·Brain : a Journal of Neurology·Aasef G ShaikhHyder A Jinnah
Mar 30, 2019·Neuroscience Research·Tadashi Yamazaki, William Lennon
Jan 16, 2020·The Cerebellum·Sinem Balta BeylergilAasef G Shaikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Mark H Yudin
BMJ : British Medical Journal
Iona Heath
Journal of the California Dental Association
Kerry K Carney
The Physician and Sportsmedicine
Susan M Kleiner
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Sharon Walmsley
© 2021 Meta ULC. All rights reserved