Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newborn.

Clinical and Experimental Immunology
B M Kumpel

Abstract

For 40 years prophylactic anti-D has been given to D-negative women after parturition to prevent haemolytic disease of the fetus and newborn. Monoclonal or recombinant anti-D may provide alternatives to the current plasma-derived polyclonal IgG anti-D, although none of them have yet proved as effective in phase 1 clinical trials. The variation in efficacy of the antibodies may have been influenced by heterogeneity in glycosylation of anti-D produced from different cell lines. Some aspects of the conduct of the human studies, most notably the use of low doses of anti-D and target D positive red cells in vivo, may aid the design of the clinical development of other immunomodulatory drugs in order to minimize adverse effects.

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Citations

Nov 22, 2013·PloS One·Dominique GoossensJean-Pierre Cartron
May 22, 2013·Expert Opinion on Biological Therapy·Sandra Easdale, Roberto Stasi
Nov 5, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mohammad Hossein AhmadiNaser Amirizadeh
Dec 24, 2013·F1000Research·André WinklerMarc Ehlers
Feb 27, 2009·Physiological Measurement·O Sayadi, M B Shamsollahi
Aug 20, 2010·Physiological Measurement·Omid SayadiGari D Clifford
Aug 10, 2018·European Journal of Human Genetics : EJHG·André Flores-BelloDavid Comas
Jul 19, 2017·Current Opinion in Hematology·Yoelys Cruz-LealAlan H Lazarus
Aug 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Honghui YuAlan H Lazarus
Jul 19, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lidice BernardoAlan H Lazarus
Jul 13, 2021·Frontiers in Immunology·Vicente Escamilla-RiveraJeanne E Hendrickson
Sep 1, 2018·The Lancet Child & Adolescent Health·Alvin ZipurskyIsaac Odame

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