LET-23-mediated signal transduction during Caenorhabditis elegans development

Molecular Reproduction and Development
P W SternbergG D Jongeward

Abstract

We are using Caenorhabditis elegans vulval induction to study intercellular signaling and its regulation. Genes required for vulval induction include the LIN-3 transforming alpha-like growth factor, the LET-23 epidermal growth factor (EGF)-receptor-like transmembrane tyrosine kinase, the SEM-5 adaptor protein, LET-60 Ras, and the LIN-45 Raf serine/threonine kinase. Inactivation of this pathway results in a failure of vulval differentiation, the "vulvaless" phenotype. Activation of this pathway either by overexpression of LIN-3, a point mutation in the LET-23 extracellular domain, or hyperactivity of LET-60 Ras results in excessive vulval differentiation, the "multivulva" phenotype. In addition to searching for new genes that act positively in this signaling pathway, we have also characterized genes that negatively regulate this inductive signaling pathway. We find that such negative regulators are functionally redundant: mutation of only one of these negative regulators has no effect on vulval differentiation; however, if particular combinations of these genes are inactivated, excessive vulval differentiation occurs. The LIN-15 locus encodes two functionally redundant products, LIN-15A and LIN-15B, that formally act upstream of...Continue Reading

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
May 1, 1974·Genetics·S Brenner
Jan 1, 1974·Humangenetik·J P FrynsH Van den Berghe
Feb 1, 1981·Developmental Biology·J E Sulston, H R Horvitz
Aug 1, 1980·Developmental Biology·J E SulstonJ N Thomson
Mar 12, 1993·Cell·Z SongyangR J Lechleider
Apr 1, 1994·Molecular Biology of the Cell·L S HuangP W Sternberg
Jul 30, 1993·Science·A Sorkin, G Carpenter
Jan 1, 1993·Molecular and Cellular Biology·R V AroianP W Sternberg

❮ Previous
Next ❯

Citations

Aug 28, 1998·Cellular Signalling·Y C Liu, A Altman
Apr 8, 1998·Current Opinion in Genetics & Development·D Van VactorB G Neel
Apr 5, 2001·Mechanisms of Development·J MihalyM Mlodzik
Sep 22, 2009·Seminars in Cell & Developmental Biology·Dana T Byrd, Judith Kimble
Nov 12, 2014·Membranes·Fubito NakatsuHiroshi Ohno
Feb 3, 2009·Traffic·Yaara Zwang, Yosef Yarden
Feb 23, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Natalia V KirienkoDavid S Fay
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Mirko H H Schmidt, Ivan Dikic
Dec 18, 2001·American Journal of Physiology. Cell Physiology·Olav OlsenPaul A Welling
Jan 25, 2002·Annals of the New York Academy of Sciences·A KalmesA W Clowes
Dec 16, 1998·Experimental Cell Research·K D IzadiD L Durden
Sep 1, 1996·Current Biology : CB·E J Lambie
Aug 30, 2005·The International Journal of Biochemistry & Cell Biology·Nathaniel J Szewczyk, Lewis A Jacobson
Jun 8, 2007·European Journal of Cell Biology·Ivan Dikic, Mirko H H Schmidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.