Nov 4, 2018

let-7 controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41

BioRxiv : the Preprint Server for Biology
Florian AeschimannHelge Grosshans

Abstract

Development of multicellular organisms relies on faithful temporal control of cell fates. In Caenorhabditis elegans, the heterochronic pathway governs temporal patterning of somatic cells. This function may be phylogenetically conserved as several heterochronic genes have mammalian orthologues, and as the heterochronic let-7 miRNA and its regulator LIN28 appear to time the onset of puberty in mice and humans. Here, we have investigated how let-7 promotes the transition to adulthood in C. elegans. We find that let-7 controls each of three relevant processes, namely male and female sexual organ morphogenesis as well as changes in skin progenitor cell fates, through the same single target, lin-41. LIN41 in turn silences two pairs of targets post-transcriptionally, by binding and silencing their mRNAs. The EGR-type transcription factor LIN-29a and its co-factor, the NAB1/2 orthologous MAB-10, mediate control of progenitor cell fates and vulval integrity. By contrast, male tail development depends on regulation of the DM domain-containing transcription factors DMD-3 and MAB-3. Our results provide mechanistic insight into an exemplary temporal patterning pathway, demonstrate that let-7 - LIN41 function as a versatile regulatory modul...Continue Reading

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Mentioned in this Paper

Calcinus elegans
Cyartonema elegans
Coleonyx elegans
Biochemical Pathway
Transcriptional Regulation
CD2BP2
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
3'-methyl-4-methylaminoazobenzene

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