Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy

Molecular Cell
Michael J Lee

Abstract

Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.

Citations

Aug 6, 2015·Journal of Molecular Biology·Benjamin D LandryMichael J Lee

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