Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs

Molecular Cell
Ligang Wu, Joel G Belasco

Abstract

The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.

References

Feb 7, 2001·Genes & Development·S M ElbashirT Tuschl
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Oct 27, 2001·Science·R C Lee, V Ambros
Jul 9, 2002·Genes & Development·Brenda J ReinhartDavid P Bartel
Aug 3, 2002·Science·György Hutvágner, Phillip D Zamore
Sep 17, 2002·Cell·Javier MartinezThomas Tuschl
Oct 9, 2002·Genes & Development·Amy A CaudyScott M Hammond
Oct 9, 2002·Genes & Development·Akira IshizukaHaruhiko Siomi
Feb 26, 2003·Genes & Development·John G DoenchPhillip A Sharp
Mar 8, 2003·Science·Lee P LimDavid P Bartel
Aug 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yan ZengBryan R Cullen
Aug 9, 2003·Genomics·Takashi SasakiNobuyoshi Shimizu
Mar 24, 2004·Cell·Yukihide TomariPhillip D Zamore
Apr 24, 2004·Science·Soraya YektaDavid P Bartel
Jul 3, 2004·Genes & Development·Katsutomo OkamuraMikiko C Siomi
Jul 21, 2004·Molecular Cell·Gunter MeisterThomas Tuschl
Jul 31, 2004·Science·Jidong LiuGregory J Hannon
Feb 17, 2005·Genes & Development·Chryssa KanellopoulouKlaus Rajewsky
May 24, 2005·Nature Cell Biology·George L Sen, Helen M Blau
Jun 7, 2005·Nature Cell Biology·Jidong LiuRoy Parker
Jun 21, 2005·Nature Genetics·Isaac BentwichZvi Bentwich
Jun 24, 2005·Nature·Thimmaiah P ChendrimadaRamin Shiekhattar
Aug 6, 2005·Science·Ramesh S PillaiWitold Filipowicz
Aug 27, 2005·Cell·Shveta BaggaAmy E Pasquinelli
Sep 24, 2005·Cell·Jeff Coller, Roy Parker

❮ Previous
Next ❯

Citations

Jan 22, 2013·Molecular Genetics and Genomics : MGG·S AroraV Rani
Mar 3, 2009·Journal of Bone and Mineral Metabolism·Kazushi TakayamaKunio Takaoka
Sep 9, 2010·Pharmaceutical Research·Ebbe J B NielsenKenneth A Howard
May 5, 2011·Molecular Neurobiology·Claire Perruisseau-CarrierColin P McGuckin
May 21, 2010·Leukemia·L Di LisioN Martínez
Feb 9, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Justin T LowKevin M Weeks
Dec 15, 2010·Nature Reviews. Neurology·Andreas JunkerEdgar Meinl
Jan 12, 2010·Nature Structural & Molecular Biology·Sergej DjuranovicRachel Green
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yong-Ick KimAndy LiWang
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kimika MakiHiroji Aiba
May 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Venigalla B Rao
Sep 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yong-Gang ChangAndy LiWang
Oct 12, 2012·The Journal of Biological Chemistry·Ravi KasiappanWenlong Bai
May 5, 2009·Molecular & Cellular Proteomics : MCP·Benoît LalooChristophe Grosset
Oct 15, 2009·Bioinformatics·Curtis HuttenhowerHilary A Coller
Jan 31, 2012·Bioinformatics·Matthew G Seetin, David H Mathews
Oct 8, 2009·Nucleic Acids Research·Grace S TanMarianthi Kiriakidou
May 21, 2010·Nucleic Acids Research·Gabriele SalesChiara Romualdi
Sep 12, 2013·Nucleic Acids Research·Jeane M GovanAlexander Deiters
Jan 29, 2009·Genes & Development·Hong SuXiaozhong Wang
Jun 3, 2010·Genes & Development·Elisa Araldi, Ernestina Schipani
Dec 18, 2008·Genome Research·Vincenzo Alessandro GennarinoSandro Banfi
Oct 2, 2012·The Plant Cell·Alberto CarbonellJames C Carrington
Aug 3, 2011·Molecular and Cellular Biology·Ulrike BruningCormac T Taylor
Jun 11, 2010·Annual Review of Biochemistry·Marc Robert FabianWitold Filipowicz
May 15, 2009·Physiological Genomics·Manoj BhaskaranLin Liu
Mar 17, 2010·BMC Bioinformatics·Jessica S Reuter, David H Mathews
Jan 8, 2010·BMC Developmental Biology·Amit AroraDavid A Simpson
Oct 25, 2011·BMC Developmental Biology·Jingwen WuChen Xu
Aug 12, 2009·Cell Communication and Signaling : CCS·Brandi N Davis, Akiko Hata
Nov 5, 2013·Algorithms for Molecular Biology : AMB·Harry A Stern, David H Mathews
Jun 18, 2010·BMC Systems Biology·Nadia FelliAlessandro Giuliani
Nov 6, 2009·PathoGenetics·Nicola MeolaSandro Banfi
May 13, 2010·Silence·Shuo Gu, Mark A Kay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.