Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development

International Journal of Biological Sciences
Fang CaoPeijun Liu

Abstract

Cell polarity is one of the most basic properties of all normal cells and is essential for regulating numerous biological processes. Loss of polarity is considered a hallmark for cancer. Multiple polarity proteins are implicated in maintenance of cell polarity. Lethal (2) giant larvae (Lgl) is one of polarity proteins that plays an important role in regulating cell polarity, asymmetric division as well as tumorigenesis. Lgl proteins in different species have similar structures and conserved functions. Lgl acts as an indispensable regulator of cell biological function, including cell polarity and asymmetric division, through interplaying with other polarity proteins, regulating exocytosis, mediating cytoskeleton and being involved in signaling pathways. Furthermore, Lgl plays a role of a tumor suppressor, and the aberrant expression of Hugl, a human homologue of Lgl, contributes to multiple cancers. However, the exact functions of Lgl and the underlying mechanisms remain enigmatic. In this review, we will give an overview of the Lgl functions in cell polarity and cancer development, discuss the potential mechanisms underlying these functions, and raise our conclusion of previous studies and points of view about the future studies.

Citations

Jun 14, 2016·Seminars in Cell & Developmental Biology·Ying GaoC Yan Cheng
Mar 16, 2017·Protoplasma·Tomáš Mazel
May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lior AlmagorWilliam I Weis
Mar 14, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maxwell T Stevens, Bernadette M Saunders

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Methods Mentioned

BETA
GTPase
gene knockout

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