PMID: 6408467Feb 1, 1983Paper

Lethal and mutagenic effects of radiation and chemicals on cultured fish cells derived from the erythrophoroma of goldfish (Carassius auratus)

Mutation Research
H Mitani

Abstract

GEM 199 cells derived from an erythrophoroma of goldfish (Carassius auratus), which had a high plating efficiency, were used to investigate the lethal and mutational effects of radiations (UV and gamma-rays) and chemicals (4NQO and MNNG). The cells were more resistant to gamma-rays than mammalian cells and CAF-MM1 cells derived from the normal fin tissue of goldfish. They were also more resistant to UV-irradiation than CAF-MM1 cells. Photoreactivation after UV-irradiation was present in GEM 199 cells for both survival and mutation. The initial shoulder of the survival curve of UV-irradiated cells was reduced greatly by caffeine, suggesting a high activity of the post-replication repair. The spontaneous mutation frequency to ouabain resistance was 1-5 X 10(-6) clones per viable cell. MNNG was effective in inducing ouabain-resistant mutation, while 4NQO and gamma-rays did not induce mutation.

References

Jan 1, 1977·Mutation Research·R F JostesL E Hopwood
May 12, 1972·Biochemical and Biophysical Research Communications·Y Fujiwara, T Kondo
Jul 23, 1969·Biochemical and Biophysical Research Communications·J E Cleaver, G H Thomas
Jan 1, 1982·Environmental Mutagenesis·R M KocanK M Sabo

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Citations

Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H Babich, E Borenfreund
Jun 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H Mitani
Aug 11, 1991·Ecotoxicology and Environmental Safety·R G Stahl
Aug 21, 2020·International Journal of Radiation Biology·Nguyen T K Vo
Aug 7, 2017·Radiation and Environmental Biophysics·Nguyen T K VoCarmel E Mothersill
Dec 23, 2004·Alternatives to Laboratory Animals : ATLA·Argelia CastañoUNKNOWN ECVAM Workshop 47
May 13, 1999·The Journal of Biological Chemistry·G Berrocal-TitoA Herrera-Estrella

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