Abstract
Histological and immunocytochemical investigations were performed on different organs (brain, duodenum and thymus) of mice following lethal (420 microg/kg) or sublethal (10 microg/kg) intraperitoneal injection of yessotoxin (YTX). No morpho-functional modifications were observed in large neurons of the cerebral and cerebellar cortex with the sub-lethal dose, nor in the cerebral cortex with the lethal dose. The duodenum also did not show significant alterations. However, there was an inflammation response to the toxin, in which blood cells and cytokines were involved. This was more evident with the lethal YTX dose. The thymus and, in general, the immune system are the main targets of YTX at both the concentrations used. Furthermore, the alterations present in the thymus may support tumorigenic implications.
References
Aug 1, 1986·The Journal of Pathology·N P Ring, B J Addis
Jan 1, 1993·Cancer·I FukaiO Tanamura
Oct 1, 1994·Toxicology and Applied Pharmacology·G B CorcoranR Buttyan
Feb 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·P CiminielloT Yasumoto
Mar 31, 1999·Trends in Biochemical Sciences·G Christofori, H Semb
May 3, 2000·Histopathology·T t Kuo
Nov 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·Emiko ItoTakeshi Yasumoto
Jul 12, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C MalagutiG P Rossini
Jan 18, 2003·Analytical Biochemistry·Silvia PierottiGian Paolo Rossini
Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·A TubaroT Yasumoto
Mar 23, 2004·Toxicon : Official Journal of the International Society on Toxinology·A FranchiniE Ottaviani
Citations
Aug 30, 2008·Marine Drugs·Beatriz PazJosé J Fernández
Apr 23, 2010·Marine Drugs·Antonella FranchiniEnzo Ottaviani
May 26, 2005·Toxicon : Official Journal of the International Society on Toxinology·Ingunn A SamdalChristopher O Miles
Feb 2, 2016·Marine Drugs·Amparo AlfonsoLuis M Botana
Jan 9, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mónica Suárez KorsnesElin Ørmen
Nov 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·Humberto J DominguezJosé J Fernández
Aug 4, 2009·Toxicon : Official Journal of the International Society on Toxinology·Carlotta Francesca OrsiSamuele Peppoloni
Aug 8, 2009·Toxicon : Official Journal of the International Society on Toxinology·A TubaroC Florio
Jul 29, 2008·Toxicon : Official Journal of the International Society on Toxinology·Tore AuneStig Larsen
Apr 12, 2008·Toxicon : Official Journal of the International Society on Toxinology·A TubaroS Sosa
Apr 4, 2009·Proteomics·Clifford YoungT William Jordan
Oct 3, 2006·Toxicology Letters·Davide MalagoliEnzo Ottaviani
Jul 16, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mónica Suárez KorsnesChristopher O Miles
Sep 26, 2013·Toxicon : Official Journal of the International Society on Toxinology·S SosaA Tubaro
Mar 24, 2011·Toxicon : Official Journal of the International Society on Toxinology·Mónica Suárez Korsnes, Arild Espenes
Aug 4, 2012·Toxicon : Official Journal of the International Society on Toxinology·Alicia Martín-LópezEmilio Molina-Grima
Aug 12, 2009·Water Research·David A CaronShane Trussell
Feb 26, 2016·Toxins·Pierre-Jean FerronValérie Fessard
Apr 15, 2017·Frontiers in Cell and Developmental Biology·Mónica Suárez Korsnes, Reinert Korsnes
Jul 20, 2018·Frontiers in Oncology·Mónica Suárez Korsnes, Reinert Korsnes