Lethal and sub-lethal yessotoxin dose-induced morpho-functional alterations in intraperitoneal injected Swiss CD1 mice

Toxicon : Official Journal of the International Society on Toxinology
A FranchiniE Ottaviani

Abstract

Histological and immunocytochemical investigations were performed on different organs (brain, duodenum and thymus) of mice following lethal (420 microg/kg) or sublethal (10 microg/kg) intraperitoneal injection of yessotoxin (YTX). No morpho-functional modifications were observed in large neurons of the cerebral and cerebellar cortex with the sub-lethal dose, nor in the cerebral cortex with the lethal dose. The duodenum also did not show significant alterations. However, there was an inflammation response to the toxin, in which blood cells and cytokines were involved. This was more evident with the lethal YTX dose. The thymus and, in general, the immune system are the main targets of YTX at both the concentrations used. Furthermore, the alterations present in the thymus may support tumorigenic implications.

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Citations

Aug 30, 2008·Marine Drugs·Beatriz PazJosé J Fernández
Apr 23, 2010·Marine Drugs·Antonella FranchiniEnzo Ottaviani
May 26, 2005·Toxicon : Official Journal of the International Society on Toxinology·Ingunn A SamdalChristopher O Miles
Feb 2, 2016·Marine Drugs·Amparo AlfonsoLuis M Botana
Jan 9, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mónica Suárez KorsnesElin Ørmen
Nov 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·Humberto J DominguezJosé J Fernández
Aug 4, 2009·Toxicon : Official Journal of the International Society on Toxinology·Carlotta Francesca OrsiSamuele Peppoloni
Aug 8, 2009·Toxicon : Official Journal of the International Society on Toxinology·A TubaroC Florio
Jul 29, 2008·Toxicon : Official Journal of the International Society on Toxinology·Tore AuneStig Larsen
Apr 12, 2008·Toxicon : Official Journal of the International Society on Toxinology·A TubaroS Sosa
Oct 3, 2006·Toxicology Letters·Davide MalagoliEnzo Ottaviani
Jul 16, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mónica Suárez KorsnesChristopher O Miles
Sep 26, 2013·Toxicon : Official Journal of the International Society on Toxinology·S SosaA Tubaro
Mar 24, 2011·Toxicon : Official Journal of the International Society on Toxinology·Mónica Suárez Korsnes, Arild Espenes
Aug 4, 2012·Toxicon : Official Journal of the International Society on Toxinology·Alicia Martín-LópezEmilio Molina-Grima
Apr 15, 2017·Frontiers in Cell and Developmental Biology·Mónica Suárez Korsnes, Reinert Korsnes

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