PMID: 8597848Jul 1, 1995Paper

Lethal arthrogryposis multiplex congenital (fetal akinesia deformation sequence, FADS)

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
H J Porter

Abstract

Arthrogryposis multiplex congenital (AMC) is the presence at birth of multiple congenital contractures in an intact skeleton. The severity of the condition is highly variable and the possible underlying causes are numerous. Fetal immobility and lesions of the brain, spinal cord, peripheral nerves and muscle, along with mechanical restriction of the fetus in utero are the pathogenic mechanisms that need to be considered. Etiological factors that have been implicated in the development of AMC include genetic conditions, infections, drugs, toxins, maternal hyperthermia, and maternal illness. This review will concentrate on the severe end of the spectrum of AMC that results in disease that is lethal pre- or postnatally, and will discuss the pathology, pathogenesis, etiology, and practical approach to this diversely expressed condition.

References

Sep 24, 1977·British Medical Journal·R Corcoran, J M Castles
Dec 1, 1978·Journal of the Neurological Sciences·A S Colling-Saltin
Dec 1, 1977·Teratology·F Wenger
Jan 1, 1978·The Journal of Pediatrics·S K ClarrenD W Smith
Jun 1, 1978·The Journal of Pediatrics·D W SmithM A Harvey
Jul 1, 1976·Archives of Neurology·H B SarnatP A Byrne
Apr 5, 1976·JAMA : the Journal of the American Medical Association·J W HansonD W Smith
May 1, 1976·Archives of Neurology·D B DrachmanJ Chase
Mar 1, 1992·Journal of Medical Genetics·J MelkiY Dumez
Feb 1, 1991·Epidemiology and Infection·T Whistler, R Swanepoel
May 1, 1991·Pediatric Pathology·K ItohH Itoh
Sep 11, 1991·American Journal of Obstetrics and Gynecology·M I EvansE P Hoffman
Jul 1, 1991·European Journal of Pediatrics·R C HennekamK P Dingemans
Sep 1, 1991·American Journal of Medical Genetics·J I Rodríguez, J Palacios
Mar 1, 1990·American Journal of Medical Genetics·P MoermanJ M Lauweryns
Aug 1, 1986·American Journal of Medical Genetics·D R WittG P Taylor
Feb 1, 1989·The American Journal of the Medical Sciences·J AbeH Yoshizawa
Sep 1, 1989·Journal of the Neurological Sciences·A FidziańskaU Burck-Lehmann
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·P Moerman, P G Barth
Jan 1, 1988·American Journal of Medical Genetics·R HervaP Sourander
Jan 1, 1988·American Journal of Medical Genetics·J E Davis, D K Kalousek
Feb 1, 1987·Neuropediatrics·G HagemanD Lindhout
Sep 1, 1987·American Journal of Medical Genetics·T Lerman-SagieM Nitzan
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·P MoermanJ M Lauweryns
Jan 1, 1985·Acta Neuropathologica·C W ChowD W Fortune
Mar 1, 1985·American Journal of Medical Genetics·R HervaU Seppänen
Oct 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·P Fleury, G Hageman
Aug 1, 1972·Journal of Neurology, Neurosurgery, and Psychiatry·D K DasturE P Bharucha
Mar 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·G M Yuill, P G Lynch

❮ Previous
Next ❯

Citations

Oct 11, 2012·ISRN Obstetrics and Gynecology·Emmanouil KalampokasDimitrios Botsis
Dec 9, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Erin R RudzinskiRobert F Hevner
Feb 3, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Y F Chan, A Sampson
Jul 19, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Isabel FilgesJudith G Hall
Jun 23, 2007·Journal of Pediatric Orthopedics·Wesley P BevanKit Song
Feb 22, 2008·Journal of Child Neurology·Gabriel Chow, C James H Padfield
Jun 24, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marina DimitrakiVasileios Liberis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
T SakamotoH Inomata
© 2021 Meta ULC. All rights reserved