Lethal dose and reproductive parameters of p-nonylphenol in rats

Archives of Andrology
C de JagerV W Sharp

Abstract

Male reproductive abnormalities may be due to an increased level of maternal estrogens affecting the developing fetus. Man is exposed to environmental estrogens in multiple ways: diet, drinking water, air, and skin, para-Nonylphenol (p-NP), an alkylphenol, has estrogenic properties. This study was performed to evaluate the potency and workable concentrations before reproductive tests could be performed. The oral LD50 (median lethal dose) value for rats was 1475 mg/kg. For both males in the reproductive test the litter size after long-term treatment at 50 mg/kg p-NP was smaller than that in the breeding records. Five females did not conceive at all.

References

May 1, 1991·Environmental Health Perspectives·A M SotoC Sonnenschein
Jun 1, 1974·Fertility and Sterility·C M Nelson, R G Bunge
Feb 2, 1995·The New England Journal of Medicine·J AugerP Jouannet
Jan 22, 1994·Lancet·J GinsburgP Hardiman
Aug 13, 1994·BMJ : British Medical Journal·D S Irvine
Jul 1, 1994·Endocrinology·R WhiteM G Parker
Oct 1, 1993·Environmental Health Perspectives·J A McLachlan
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek

❮ Previous
Next ❯

Citations

Oct 14, 2006·The Journal of Reproduction and Development·Naoko KimuraKiyoshi Totsukawa
Dec 6, 2012·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Reda H Elmazoudy, Azza A Attia
Jul 22, 2018·Journal of Applied Toxicology : JAT·Xiaomeng LiHuihui Bao
Oct 6, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Xu JieLi Yan
Jul 15, 2020·Andrologia·Mahdi MalmirHamideh Khodabandelo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.