Mar 1, 1979

Lethal irradiation: treatment with immune cell populations

Annals of Plastic Surgery
M A Mandel

Abstract

Lethally irradiated mice have been successfully treated by the inoculation of allogeneic spleen cell populations, without the development of a secondary graft-versus-host (GVH) reaction. This has been accomplished by eliminating those cells responsible for GVH reaction, using a density gradient ultracentrifugation technique. The therapeutic potential for this technique is great. It may well provide a modus operandi to treat patients exposed to otherwise lethal doses of radiation, as well as facilitate therapy of patients with cancer and immune deficiency diseases.

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Mentioned in this Paper

Centrifugation, Density Gradient
Immune System Diseases
Mice, Inbred BALB C
Spleen
Graft-vs-Host Disease
Graft Survival
Graft Vs Host Reaction
Isogenic Transplantation
Spleen Tissue
Transplantation, Homologous

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