PMID: 9178258Apr 1, 1997Paper

Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila

Mechanisms of Development
B GiebelJ A Campos-Ortega

Abstract

Classical genetics indicates that the achaete-scute gene complex (AS-C) of Drosophila promotes development of neural progenitor cells. To further analyze the function of proneural genes, we have studied the effects of Gal4-mediated expression of lethal of scute, a member of the AS-C, during embryogenesis. Expression of lethal of scute forces progenitor cells of larval internal sensory organs, which are normally committed to this fate independently of the activity of the AS-C, to take on features of external sensory organs. Supernumerary neural cells can be induced ectopically only if daughterless is overexpressed, either alone or together with lethal of scute: cells of the amnioserosa and the hindgut then express neuronal markers. Furthermore, cells of the proctodeal anlage, which normally lack neural competence, acquire the ability to develop as neuroblasts following transplantation into the neuroectoderm. We show here that activated Notch prevents the cells of the neuroectoderm from forming extra neural tissue when they express an excess of proneural proteins. Under the present conditions, lateral inhibition is thus dominant over the activity of proneural genes.

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Citations

Feb 9, 2010·The Journal of Biological Chemistry·Arkadiusz WelmanMargaret C Frame
Mar 12, 2005·BMC Developmental Biology·Lee-Peng MokCedric Wesley
Dec 19, 2009·PLoS Pathogens·Mathilde GendrinBruno Lemaitre
Apr 21, 2009·The International Journal of Developmental Biology·Ralston M Barnes, Anthony B Firulli
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Phoebe TzouBruno Lemaitre
Nov 10, 2010·Development Genes and Evolution·Margaret SonnenfeldXuetao Sun
Nov 10, 2010·Development Genes and Evolution·Tatiana MorozovaMargaret Sonnenfeld
Oct 27, 2004·Developmental Biology·Joseph B KearneyStephen T Crews
Oct 18, 2000·Journal of Theoretical Biology·L Acerenza
Jan 10, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tomoki IshibashiKenji Matsuno
Jan 22, 2013·Nature·Takefumi Kondo, Shigeo Hayashi
Nov 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Firzan NainuYoshinobu Nakanishi

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