PMID: 9539365Apr 16, 1998Paper

Lethal peracute rhabdomyolysis associated with stress and general anesthesia in three dystrophin-deficient cats

Veterinary Pathology
F GaschenM Adé-Damilano

Abstract

Three cats affected with dystrophin deficiency and hypertrophic muscular dystrophy developed peracute rhabdomyolysis with a fatal outcome. Two cats were anesthetized with isoflurane for routine procedures and did not recover properly from the anesthetic procedure. One cat was manually restrained for an echographic examination and started staggering after a short struggle; its condition worsened, and it died. Blood chemistry findings included severe hyperkalemia, hyperphosphatemia, hypocalcemia, massive increases in creatine kinase, aspartate aminotransferase, and alanine aminotransferase concentrations, and high ion gap metabolic acidosis. Light microscopic evaluation of skeletal muscle revealed severe acute rhabdomyolysis with marked extensive necrosis of large groups of fibers and endomysial edema. These lesions were observed in many skeletal muscles but particularly in the masseter and supraspinatus muscles and in the diaphragm. Typical changes associated with dystrophin deficiency in cats were also noted. Histochemical analysis revealed that the dystrophin deficiency was associated with a decrease in the percentage of type 1 myofibers in all three cats. This change was marked in the 20-month-old cat and milder in the younge...Continue Reading

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Citations

Nov 18, 2004·Journal of Feline Medicine and Surgery·Frédéric GaschenBoyd Jones
Mar 20, 2010·Journal of Feline Medicine and Surgery·Itamar ArochGilad Segev
May 26, 2004·The Veterinary Journal·J HowardF Gaschen
Dec 16, 2010·Journal of Veterinary Internal Medicine·J E SykesR E Goldstein
Jun 14, 2012·BMC Genomics·Dan J NonnemanGary A Rohrer
Jan 14, 2012·Physical Medicine and Rehabilitation Clinics of North America·Joe N KornegayKathryn R Wagner
Aug 8, 2013·Paediatric Anaesthesia·Leal G SeguraJuraj Sprung
Mar 1, 2014·Veterinary Pathology·G RemmersS J Valberg
May 21, 2017·Skeletal Muscle·Joe N Kornegay
Jul 23, 2002·Journal of Applied Physiology·Jon F WatchkoEric P Hoffman
Jan 22, 2014·Journal of the American Animal Hospital Association·Anya N GambinoNena J Winand
May 17, 2011·The Veterinary Record·Ken Smith
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté

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