Lethal poisonings with AH-7921 in combination with other substances

Forensic Science International : Synergy
Ritva A KarinenÅse Marit Leere Øiestad

Abstract

AH-7921 is a synthetic μ-opioid agonist, approximately equipotent with morphine. We report the death of two young individuals after ingestion of AH-7921 in combination with other psychoactive drugs. In the first case a young man died shortly after ingesting Internet drugs. Toxicological analysis of post mortem peripheral blood revealed AH-7921 (0.43 mg/L), 2-FMA (0.0069 mg/L) and 3-MMC (0.0021 mg/L) as well as codeine (0.42 mg/L), codeine-6-glucuronide (0.77 mg/L) and acetaminophen (18.7 mg/L). The second case involved a young female found dead at home. The only positive finding at medicolegal autopsy was needle marks. Toxicological analysis revealed AH-7921 (0.33 mg/L), methoxetamine (MXE) (0.064 mg/L), etizolam (0.27 mg/L), phenazepam (1.33 mg/L), 7-aminonitrazepam (0.043 mg/L), diazepam (0.046 mg/L), nordiazepam (0.073 mg/L), and oxazepam (0.018 mg/L) in blood. In both cases intoxication with AH-7921 in combination with other psychoactive drugs was considered to be the cause of death.

References

Jun 1, 1979·Biulleten' eksperimental'noĭ biologii i meditsiny·V G Zin'kovskiĭS A Andronati
Oct 1, 1989·European Journal of Drug Metabolism and Pharmacokinetics·L MartinezA Bartlett
Nov 1, 1974·Journal of Medicinal Chemistry·N J HarperD G Wibberley
Jul 1, 1980·British Journal of Pharmacology·M B Tyers
Jul 1, 1983·British Journal of Pharmacology·A G Hayes, M B Tyers
Jan 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·V P ZherdevA L Ekonomov
Mar 9, 2000·Addiction·J M White, R J Irvine
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·B K ParkP M O'Neill
Nov 2, 2005·European Journal of Clinical Pharmacology·T FukasawaK Otani
Jun 25, 2008·Chest·Mohammed MogriM Jeffrey Mador
May 31, 2011·Journal of Analytical Toxicology·Elisabeth Leere OiestadAsbjørg Solberg Christophersen
Oct 11, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jeanine WardEdward Boyer
Dec 30, 2011·European Journal of Clinical Pharmacology·David M WoodPaul I Dargan
Jan 10, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sandra Rinne DahlDag Helge Strand
Jan 18, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Simon Gibbons
Mar 7, 2012·Forensic Science International : Synergy·Pirkko KriikkuIlkka Ojanperä
Nov 1, 2012·Journal of Analytical Toxicology·Maria WikströmRobert Kronstrand
Jul 5, 2013·Journal of Forensic Sciences·Kilak KeshaDavid R Fowler
Feb 14, 2014·Journal of Analytical Toxicology·Shawn P VorceThomas Z Bosy
Feb 18, 2014·Journal of Forensic Sciences·Albert A Elian, Jeffery Hackett
May 9, 2014·Forensic Science International : Synergy·Simon Elliott, Julie Evans
Jul 6, 2014·Drug Testing and Analysis·Simon D BrandtMichael Evans-Brown
Jul 26, 2014·International Journal of Occupational Medicine and Environmental Health·Marek WiergowskiZbigniew Jankowski

Citations

Nov 26, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Matilda BäckbergAnders Helander
Oct 21, 2015·Drug and Alcohol Dependence·Jolanta B Zawilska, Dariusz Andrzejczak
Mar 12, 2016·Bioanalysis·Elisabeth L ØiestadRitva A Karinen
Apr 8, 2015·Drug Testing and Analysis·Megan L CrichtonPeter D Maskell
May 5, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Silja S TuvVigdis Vindenes
Jul 14, 2016·Journal of Analytical Toxicology·Carole JameyJean-Sébastien Raul
Jul 28, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Aaron SchneirRobert L Fitzgerald
Jun 8, 2017·Journal of Addiction Medicine·Matthew P PrekupecMichael H Baumann
Oct 30, 2018·Journal of Analytical Toxicology·Michael T Truver, Madeleine J Swortwood
Apr 4, 2020·Drug and Alcohol Review·Suzanne Nielsen, Andrew McAuley
May 6, 2020·Journal of Analytical Toxicology·Gunhild HeideÅse Marit Leere Øiestad
Nov 13, 2018·Frontiers in Pharmacology·Marta ConcheiroGail Cooper
Jul 6, 2018·Frontiers in Pharmacology·Renata SoliminiRaffaele Giorgetti
Jul 18, 2017·Frontiers in Psychiatry·Jolanta B Zawilska
Sep 12, 2018·Brain Sciences·Paolo FrisoniMatteo Marti
May 7, 2018·Forensic Sciences Research·Olaf H Drummer
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Jun 16, 2018·Proceedings·Kerry Anne RambaranSaeed K Alzghari
Jan 13, 2019·International Journal of Environmental Research and Public Health·Barbara LovrecicIcro Maremmani
Jul 16, 2019·Forensic Sciences Research·Inês TabarraEugenia Gallardo
May 2, 2017·Journal of Analytical Toxicology·Barry K LoganMarilyn A Huestis
Nov 26, 2020·Medicine, Science, and the Law·Laura J HikinStephen R Morley
Dec 3, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Piotr Adamowicz
Oct 9, 2020·Journal of Analytical Toxicology·Jirair GevorkyanLuke N Rodda

Related Concepts

Acetaminophen
Alcoholic Intoxication
Autopsy
Blood
Codeine
Cessation of Life
Diazepam
Morphine
Needle Device
Oxazepam

Related Feeds

Catatonic Schizophrenia

Catatonia is a psychomotor symptom in which patients present with stupor, although catatonic excitement may also present at the other end of the spectrum. Catatonia has been historically associated with schizophrenia although it is also associated with other neuropsychiatric disorders. Find the latest research on catatonic schizophrenia here.

Related Papers

Forensic Science International : Synergy
Ritva A KarinenVigdis Vindenes
Actas luso-españolas de neurología y psiquiatría
J M Darder Cicera
Farmakologiia i toksikologiia
G M AleksandrovaG P Milogradova
Beiträge zur gerichtlichen Medizin
A Moosmayer, K Besserer
© 2021 Meta ULC. All rights reserved