PMID: 2125638Nov 1, 1990Paper

Lethal short-bowel syndrome

Journal of Pediatric Surgery
B J Hancock, N E Wiseman

Abstract

Infants with short-bowel syndrome are difficult to manage. Despite supportive measures with parenteral nutrition and surgery to lengthen remaining bowel or increase functional absorptive surface area, the outcome for many of these infants is poor. We have reviewed a series of seven infants diagnosed with severe short bowel. Causes included volvulus (3), multiple atresias (2), and total intestinal aganglionosis (2). Survival time ranged from 15 days to 8 months. During the hospital course, each infant underwent one to three operative procedures to diagnose and manage the short bowel and all received total parenteral nutrition (TPN) ranging from 10 days to 6 months. One infant died of liver failure and two others developed significant liver dysfunction secondary to TPN. Most infants remained hospitalized until their death. Death occurred at an average of 9 weeks following the diagnosis of short-bowel syndrome. This review suggests that infants with less than 6 cm of small bowel beyond the Ligament of Treitz will inevitably die of their disease or treatment complications. Until bowel transplant becomes a viable alternative, operative intervention and nutritional support may prolong survival but will not change the outcome of these...Continue Reading

References

Apr 1, 1976·Journal of Pediatric Surgery·V C Talwalker
Jan 1, 1987·Journal of Pediatric Surgery·M M ZieglerH C Bishop
Aug 1, 1985·The British Journal of Surgery·M Di LorenzoP Brochu
Aug 1, 1985·Journal of Pediatric Surgery·D A CanianoJ L Hill
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Dec 1, 1981·Journal of Pediatric Surgery·C R Boeckman, R Traylor

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Citations

Jun 1, 1994·Diseases of the Colon and Rectum·R Blanco-Benavides, J Niño
May 1, 1995·Journal of Pain and Symptom Management·S Mercadante
Sep 1, 1994·Baillière's Clinical Gastroenterology·A D Mayer
Jan 1, 1995·Critical Reviews in Oncology/hematology·S Cascinu
Oct 21, 2004·Best Practice & Research. Clinical Gastroenterology·Jutta KellerPeter Layer
Nov 30, 2000·Obstetrics and Gynecology·M J BarsoomG W Turner
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·J SchalamonM E Höllwarth
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·Geert I KoffemanRoeland A Veenendaal
May 14, 2008·Transplantation·Sameera I MianRicardo O Castillo
Feb 1, 1995·Archives of Disease in Childhood·J W Puntis
Jan 9, 2004·Pediatric Clinics of North America·Naveen K MittalJohn F Thompson
Aug 28, 2012·Revista de gastroenterología de México·D ValdovinosJ Ramírez-Mayans
Apr 1, 1994·The British Journal of Surgery·L K Shanbhogue, J C Molenaar
Aug 2, 2007·Journal of Pediatric Gastroenterology and Nutrition·Ljubomir RossiSaleh Al-Nassar
Aug 1, 1995·Scandinavian Journal of Gastroenterology·M PakarinenP Kuusanmäki
Sep 19, 2003·European Journal of Pediatrics·René SeverijnenGer Bongaerts
May 1, 2001·Pediatric Transplantation·S S KaufmanUNKNOWN American Society of Transplantation

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