PMID: 44036Oct 1, 1979

Lethal synergism between morphine or other narcotic analgesics and propranolol

Toxicology
W M Davis, N S Hatoum

Abstract

Interactions of (+/-)-propranolol HCl with various narcotics were determined in albino rats. The 24-h intraperitoneal (i.p.) LD50 of morphine sulfate + saline was 15--16 times greater than for morphine + propranolol in both sexes although morphine was nearly twice as toxic to males as to females. The potency ratios for LD50's with saline vs. with propranolol were: codeine, 1.9, (+/-)-methadone, 6.0; (-)-alpha-acetylmethadol, 2.8 (72 h). The toxicity of levorphanol also was greatly increased with propranolol, but the dose-effect relationship showed non-parallelism vs. levorphanol + saline. Albino mice and mongrel dogs also showed synergism between morphine and propranolol. Mortality after morphine and propranolol was antagonized by naloxone or naltrexone in rats and mice. The potency ratio in rats for morphine + saline vs. morphine + practolol was 3.5. However, the synergism between propranolol and the narcotics probably was unrelated to beta-adrenergic blocking effects of propranolol because of the apparent equivalence of (+)-, (-)- and (+/-)-propranolol in rats for synergism with morphine.

References

Dec 21, 1976·Psychopharmacology·G NavarroA T Zuban
Jan 1, 1976·Annals of the New York Academy of Sciences·M J KreekF H Field
Dec 15, 1975·Life Sciences·J E Milmore, K M Taylor
Dec 15, 1974·Life Sciences·R A Mannino, H H Wolf
Aug 1, 1965·The Journal of Pharmacy and Pharmacology·G Leszkovszky, L Tardos
Oct 1, 1966·The Journal of Pharmacy and Pharmacology·W MurmannM Saccani-Guelfi

Citations

Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·J N McDougalT F Burks
Mar 30, 2007·Chirality·Imran AliBhavtosh Sharma
Aug 20, 2003·Journal of Psychoactive Drugs·Benjamin Thomas
Oct 1, 1988·Journal of Psychoactive Drugs·K L Jansen, C J Prast
Jan 1, 1989·Journal of Psychoactive Drugs·M Winkelman, M Dobkin de Rios
Oct 1, 1986·Journal of Psychoactive Drugs·R Leverant
Apr 1, 1981·Drug Intelligence & Clinical Pharmacy·W M Davis, N S Hatoum
May 1, 1988·Drug Intelligence & Clinical Pharmacy·H D Kerr

Related Concepts

Opioids
Metazoa
Canis familiaris
Drug Augmentation
Injections, Intraperitoneal
Lethal Dose 50
Morphine Sulfate (2: 1), Pentahydrate
Rexigen
Molecular Stereochemistry
Mouse, Swiss

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Postgraduate Medical Journal
M A Frais, T J Bayley
Dermatology : International Journal for Clinical and Investigative Dermatology
J L SchmutzM N Gillet-Terver
© 2021 Meta ULC. All rights reserved