PMID: 8613683Mar 1, 1996Paper

Lethality of radiation-induced chromosome aberrations in human tumour cell lines with different radiosensitivities

International Journal of Radiation Biology
J Coco-MartinA C Begg

Abstract

In order to find an explanation for the eventual disappearance of all chromosome aberrations in two radiosensitive human tumour cell lines, the type and stability of different aberration types was investigated in more detail. To classify the aberrations into unstable and stable types, three-colour fluorescence in situ hybridization was performed, including a whole-chromosome probe, a pancentromere probe, and a stain for total DNA. This technique enables the appropriate classification of the aberrations principally by the presence (stable) or not (unstable) of a single centromere per chromosome. Unstable-type aberrations were found to disappear within 7 days (several divisions) in the two radiosensitive and the two radioresistant tumour lines investigated. Stable-type aberrations were found to remain at an approximately constant level over the duration of the experiment (14 days; 8-10 divisions) in the two radioresistant lines. In contrast, the majority of these stable-type aberrations had disappeared by 14 days in the two radiosensitive lines. The previous findings of disappearance of total aberrations in radiosensitive cells was therefore not due to a reduced induction of stable-type aberrations, but the complete disappearance...Continue Reading

References

Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J S Bedford
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R R WeichselbaumT J Ervin
Feb 1, 1973·Journal of Theoretical Biology·A V Carrano, J A Heddle
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·W C DeweyD B Leeper
Jun 1, 1993·International Journal of Radiation Biology·R C Moore, M A Bender
Nov 1, 1993·Molecular and Cellular Biology·B A Marder, W F Morgan

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Citations

May 11, 2004·Journal of Radiation Research·Natasja Castro KrederJaap Haveman

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