Lethargus is a Caenorhabditis elegans sleep-like state

Nature
David M RaizenAllan I Pack

Abstract

There are fundamental similarities between sleep in mammals and quiescence in the arthropod Drosophila melanogaster, suggesting that sleep-like states are evolutionarily ancient. The nematode Caenorhabditis elegans also has a quiescent behavioural state during a period called lethargus, which occurs before each of the four moults. Like sleep, lethargus maintains a constant temporal relationship with the expression of the C. elegans Period homologue LIN-42 (ref. 5). Here we show that quiescence associated with lethargus has the additional sleep-like properties of reversibility, reduced responsiveness and homeostasis. We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regulator of sleep-like behaviour, and show that egl-4 functions in sensory neurons to promote the C. elegans sleep-like state. Conserved effects on sleep-like behaviour of homologous genes in C. elegans and Drosophila suggest a common genetic regulation of sleep-like states in arthropods and nematodes. Our results indicate that C. elegans is a suitable model system for the study of sleep regulation. The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to al...Continue Reading

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Citations

Jun 29, 2011·Pflügers Archiv : European journal of physiology·Urs Albrecht
Dec 11, 2013·Journal of Neuroscience Methods·Chih-Chieh Jay YuChristopher Fang-Yen
Nov 6, 2013·Pharmacology & Therapeutics·M DreslerF Holsboer
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