PMID: 22559024May 9, 2012Paper

Letter: Human papilloma virus and molluscum contagiosum lesions related to infliximab therapy for psoriasis: a case series

Dermatology Online Journal
S GeorgalaC Georgala

Abstract

Biological therapy for psoriasis exerts its action via an immunomodulatory and eventually immunosuppressive mode. Immunosuppression is linked to HPV flares. Our purpose is to investigate a possible relationship between infliximab therapy for psoriasis and human papilloma virus and molluscum (HPV/MC) infections. We report a case series of three patients with psoriasis on infliximab, who developed HPV/MC lesions following their treatment. Our patients developed HPV/MC lesions within a few months after the initiation of infliximab infusions for psoriasis. Immunosuppresion is related to HPV/MC flares. Biological therapy and in particular infliximab treatment acts by immunomodulation and eventually a degree of immunosuppression. Anti-TNF treatment could be associated with HPV and/or MC flares. For this reason, we suggest the consideration of obtaining a routine cervical PAP smear before the commencement and during treatment with anti-TNF agents for psoriasis.

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