Abstract
Anti-Leu-7 (HNK-1, CD 57) antibody, a marker for natural killer lymphocytes, was employed by Ghali et al. (Hum Pathol 1992;23: 21-25) to study surgically resected formalin-fixed, paraffin-embedded thyroid lesions. They demonstrated strong immunoreactivity of this antibody with thyroid carcinomas, both follicular and papillary, and only occasional weak immunoreactivity with colloid goiters and follicular adenomas. We studied cytologic specimens (primarily fine-needle aspiration biopsy specimens) from 44 thyroid lesions, including 10 follicular carcinomas, 14 follicular adenomas, seven adenomatous nodules, six papillary carcinomas, and seven cases of Hashimoto's thyroiditis. All follicular carcinomas exhibited immunoreactivity to anti-Leu-7 antibody, usually of a moderate to strong degree (9/10); however, six of 14 follicular adenomas yielded similar results. The patterns of immunoreactivity in the other lesions were similar to those previously described (Ghali et al., Hum Pathol 1992;23:21-25). It does not appear that anti-Leu-7 antibody can be used as a specific marker of malignancy in the cytologic assessment of follicular neoplasms of the thyroid.
References
Jan 1, 1992·Human Pathology·V S GhaliR L Garcia
Aug 1, 1992·Human Pathology·T HiroseK Hizawa
Dec 1, 1992·Human Pathology·E CampoW Stetler-Stevenson
Jul 15, 1985·Cancer·J J RusthovenP H Pinkerton
Jan 1, 1986·The American Journal of Surgical Pathology·T KodamaN Miyazawa
Jan 1, 1988·Diagnostic Cytopathology·M S ShurbajiJ K Frost
Dec 1, 1989·The American Journal of Surgical Pathology·G VialeM Gambacorta
Jun 1, 1986·American Journal of Clinical Pathology·M B CohenJ H Beckstead
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·H HoeflerP U Heitz
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·S SchröderW W Franke
Aug 1, 1987·Journal of the American Academy of Dermatology·J KanitakisJ Thivolet
Dec 1, 1988·Cancer·R González-CámporaH Galera-Davidson
Sep 1, 1987·Diagnostic Cytopathology·M AltmannsbergerM Droese
Mar 1, 1988·Diagnostic Cytopathology·K C Suen
Dec 15, 1987·Cancer·S MichelsM R Wick
Jan 1, 1986·Diagnostic Cytopathology·B AtkinsonV A LiVolsi
Apr 1, 1985·Diagnostic Cytopathology·S R KiniM J Smith-Purslow
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Tuccari, G Barresi
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Nov 10, 1983·Nature·S Schuller-PetrovicD Kraft
Nov 24, 1983·Nature·R C McGarryJ C Roder
Jul 15, 1984·Cancer·S C Logmans, A C Jöbsis
Nov 1, 1984·American Journal of Clinical Pathology·W R GeddieH T Strawbridge
Jul 1, 1981·Clinics in Endocrinology and Metabolism·J S Willems, T Löwhagen
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·W BöckerM Brassow
Citations
Aug 1, 1996·The American Journal of Surgical Pathology·M L Ostrowski, M J Merino
Sep 25, 2001·The Laryngoscope·R G Amedee, N R Dhurandhar
Aug 6, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sherif Rezk, Ashraf Khan
Sep 1, 2006·Cancer·Vishal S ChandanKamal K Khurana
Apr 16, 2002·Histopathology·K T MaiA S Commons
Mar 27, 2012·Endocrine Journal·Homero Gustavo Correia RodriguesLuis Fernando Fernandes Adan