PMID: 15377887Sep 21, 2004Paper

Leucine acutely reverses burn-induced alterations in translation initiation in heart

Shock
C H LangR A Frost

Abstract

Myocardial dysfunction is a common manifestation of thermal injury, the etiology of which appears to be multifactorial. We have previously demonstrated that burn injury impairs cardiac protein synthesis at the level of translation initiation. The purpose of the present study was to determine whether oral administration of leucine, which is known to stimulate translation initiation in skeletal muscle, can ameliorate burn-induced changes in signal transduction pathways known to regulate protein synthesis in cardiac muscle. To address this aim, thermal injury was produced by a 40% total body surface area full-thickness scald burn in anesthetized rats, and the animals were studied in the fasted condition 24 h later; appropriate time-matched nonburned control rats were also included. Separate groups of control and burn rats also received an oral gavage of leucine. To identify potential mechanisms responsible for regulating mRNA translation in cardiac muscle, several eukaryotic initiation factors (eIFs) were examined using immunoprecipitation and immunoblotting techniques. Hearts from burned rats demonstrated a redistribution of eIF4E as evidenced by the increased binding of the translational repressor 4E-BP1 with eIF4E, a decreased ...Continue Reading

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Citations

Jan 25, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Juquan SongMarc G Jeschke
Sep 18, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph F PierreKenneth A Kudsk
Nov 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeffery EscobarTeresa A Davis
Jan 7, 2010·American Journal of Physiology. Endocrinology and Metabolism·Cossette Sanchez CanedoLuc Bertrand
Dec 21, 2005·The Journal of Nutrition·Jean-Pascal De Bandt, Luc Cynober

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