Leucine and methionine deficiency impairs immunity to gastrointestinal parasites during lactation.

The British Journal of Nutrition
P SakkasI Kyriazakis

Abstract

Lactating rats reinfected with Nippostrongylus brasiliensis fed low-crude protein (CP) foods show reduced lactational performance and less resistance to parasites compared with their high-CP counterparts. Here, we hypothesised that feeding high-CP foods deficient in specific essential amino acids (AA) would result in similar penalties. Second-parity lactating rats, immunised with 1600 N. brasiliensis infective larvae before mating, were fed foods with either 250 (high protein; HP) or 150 (low protein; LP) g CP/kg, or were HP deficient in either leucine (HP-Leu) or methionine (HP-Met). On day 1 of lactation, litter size was standardised at twelve pups. On day 2, dams were either reinfected with 1600 N. brasiliensis larvae or sham-infected with PBS. Dams and litters were weighed daily until either day 8 or 11, when worm burdens, and inflammatory cells and systemic levels of N. brasiliensis-specific Ig isotypes were assessed. Data from five out of sixteen HP-Met rats were omitted due to very high levels of food refusals from parturition onwards. Relative to feeding HP foods, feeding LP, HP-Met and HP-Leu foods reduced dam weight gain and, to a lesser extent, litter weight gain, and increased the number of worm eggs in the colon, i...Continue Reading

References

Dec 1, 1986·The American Journal of Clinical Nutrition·A G CumminsA E Davis
Mar 15, 1981·The Biochemical Journal·J R Viña, D H Williamson
Jan 1, 1994·The British Journal of Nutrition·A P PineJ D Oldham
May 1, 1997·Journal of Animal Science·N L TrottierR A Easter
Jul 3, 1998·The Journal of Nutrition·S DeSantiagoS M Hutson
Aug 4, 1998·The Journal of Nutrition·G Wu
May 15, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·C C Zouboulis
Aug 24, 1999·Veterinary Parasitology·R L Coop, I Kyriazakis
Jun 19, 2002·The Proceedings of the Nutrition Society·J G HoudijkI Kyriazakis
Jul 26, 2003·The Biochemical Journal·Russell HydeHarinder S Hundal
Sep 13, 2003·Parasite Immunology·Catherine E Lawrence
Sep 18, 2003·The British Journal of Nutrition·Jos G M HoudijkIlias Kyriazakis
Oct 28, 2004·American Journal of Physiology. Endocrinology and Metabolism·Emma J ClowesVickie E Baracos
Jun 11, 2005·The British Journal of Nutrition·Jos G M HoudijkIlias Kyriazakis
Dec 21, 2005·The Journal of Nutrition·Phillip C Calder
May 17, 2006·The Journal of Nutrition·Robert F Grimble
Mar 3, 2007·Annual Review of Nutrition·Dorothy W GietzenTracy G Anthony
Apr 4, 2007·The British Journal of Nutrition·Peng LiGuoyao Wu
Aug 2, 2008·Amino Acids·W W WangD F Li
Nov 1, 1948·The Journal of Nutrition·G M MARUYAMA, P H PHILLIPS
Mar 21, 2009·Amino Acids·Guoyao Wu
May 22, 2009·Journal of Pediatric Gastroenterology and Nutrition·Maaike W SchaartIngrid B Renes
Jan 19, 2010·Nutrition·Amany K ElshorbagyCarmen E Perrone
Jul 9, 2011·The British Journal of Nutrition·Panagiotis SakkasIlias Kyriazakis

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Citations

Nov 21, 2020·Tropical Animal Health and Production·Muhammad NaeemNabila Roohi

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