Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease

Peptides
Dong Joo YangKi Woo Kim

Abstract

The skin responds to environmental stressors by coordinated actions of neuropeptides and their receptors. An endogenous peptide for δ-opioid receptor (DOPr), Leu-enkephalin (L-ENK), is expressed in the skin and its expression is altered in pathological conditions. Although the importance of DOPr is rapidly gaining recognition, the molecular mechanisms underlying its effects on wound healing are largely undefined. We show here that L-ENK induced activation of Erk, P90(RSK), and Elk-1 and promoted the disruption of hemidesmosomes and the expression of matrix metalloprotease (MMP)-2 and MMP-9, important processes for wound healing. Treatment with Erk inhibitor blocked activation of P90(RSK) and Elk-1 and significantly blunted wound repair. Therefore, our results suggest that activation of Erk and its downstream effectors, P90(RSK) and Elk-1, are critical for DOPr-mediated skin homeostasis.

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Citations

Nov 10, 2018·Pain·Annabelle Reaux-Le GoazigoStéphane Melik Parsadaniantz
Nov 2, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Adriana MuchowskaPiotr Kosson
Jul 21, 2020·ELife·Cristina Peligero-CruzJakub Abramson
Oct 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Joo YangKi Woo Kim

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