Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation

The Journal of Endocrinology
P FuA L Gundlach

Abstract

Leucine-rich repeat-containing G-protein-coupled receptor 8 (LGR8, or RXFP2) is a member of the type C leucine-rich repeat-containing G protein-coupled receptor family, and its endogenous ligand is insulin-like peptide-3 (INSL3). Although LGR8 expression has been demonstrated in various human tissues, including testis, ovary, brain and kidney, the precise roles of this receptor in many of these tissues are unknown. In an effort to better understand INSL3-LGR8 systems in the rat, we cloned the full-length Lgr8 cDNA and investigated the presence and cellular localization of Lgr8 mRNA expression in adult and developing rat kidney. On the basis of these findings, we investigated the presence and distribution of renal 125I-labelled human INSL3-binding sites and the nature of INSL3-LGR8 signalling in cultured renal cells. Thus, using in situ hybridization histochemistry, cells expressing Lgr8 mRNA were observed in glomeruli of renal cortex from adult rats and were tentatively identified as mesangial cells. Quantitative, real-time PCR analysis of the developmental profile of Lgr8 mRNA expression in kidney revealed highest relative levels at late stage gestation (embryonic day 18), with a sharp decrease after birth and lowest levels in...Continue Reading

Citations

May 30, 2013·PloS One·Aurélie Allais-BonnetAurélien Capitan
May 7, 2009·Annals of the New York Academy of Sciences·Mary FamilariLaura J Parry
Dec 17, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ishanee MookerjeeChrishan S Samuel
Sep 12, 2018·Human Reproduction Update·Richard Ivell, Ravinder Anand-Ivell
Jan 11, 2013·Physiological Reviews·R A D BathgateR J Summers
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuliang RanZhihua Yang
Aug 18, 2020·General and Comparative Endocrinology·Richard IvellRavinder Anand-Ivell
Sep 29, 2020·Protein and Peptide Letters·Paolo FacondoAlberto Ferlin

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