PMID: 6540190Jul 1, 1984Paper

Leucocyte adherence inhibition assay (LAI) in cancer of the oral cavity

European Journal of Cancer & Clinical Oncology
B PrabhaD M Vasudevan

Abstract

Antitumor immunity to oral cancer was assessed in 46 patients suffering from squamous cell carcinoma of the oral cavity using a leucocyte adherence inhibition assay (LAI). The response shown by the leucocytes of oral cancer patients to the oral cancer antigen was compared to that shown by the leucocytes from 10 normal age- and sex-matched healthy controls and 43 patients suffering from other types of cancers. Seventy-six percent of the oral cancer patients showed a high degree of leucocyte adherence inhibition in the presence of the antigen. The specificity of this test was further assessed using combinations of the leucocytes from oral cancer patients with extracts from seven cancers occurring at various other sites and extracts of normal oral tissue. The test was highly specific and the leucocytes of oral cancer patients showed significant inhibition only in the presence of oral cancer extract. The inhibition was between 0 and 30% with most other cancer extracts except in the case of extract from cancer of the cervix, where 4/10 patients showed above 30% inhibition. Specific blocking of the LAI response was observed on addition of sera from oral cancer patients to leucocyte-antigen mixtures from oral cancer patients. This eff...Continue Reading

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Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·P BalaramM K Nair
Jan 1, 1994·European Journal of Cancer. Part B, Oral Oncology·P BalaramM K Nair
Dec 23, 2009·Cancer Biotherapy & Radiopharmaceuticals·Vino T CheriyanPrabha Balaram
Oct 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J E Hoppe
Jun 1, 1986·European Journal of Clinical Microbiology·J E Hoppe, R Vogl
Mar 1, 1992·Head & Neck·R SankaranarayananS C Dutt

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