PMID: 9186539Apr 1, 1997Paper

Leucocyte and platelet-derived bioactive substances in stored blood: effect of prestorage leucocyte filtration

European Journal of Haematology
H J NielsenP S Skov

Abstract

Adverse reactions to transfusion of allogeneic blood may depend on content of leucocytes and platelets and on storage-time of the erythrocyte suspensions. Therefore, we studied the efficacy of prestorage leucocyte reduction by filtration on total content and extracellular accumulation of histamine, eosinophil cationic protein (ECP), eosinophil protein X (EPX), myeloperoxidase (MPO), plasminogen activator inhibitor type-1 (PAI-1) and interleukin-6 (IL-6) in samples obtained from 5 units of SAGM blood, 7 units of plasma-reduced whole-blood and 6 units of whole-blood before and after filtration, respectively. In addition, we analysed supernatants from the same units after storage at +4 degrees C for 0, 21 and 35 d, respectively. The filtration was performed at room temperature within 2-4 h after donation. The substances were analysed by ELISA and RIA methods and we also analysed the donor plasma levels of the same bioactive substances. The total content of histamine, ECP, EPX, and MPO were 10-70-fold higher in all unfiltered erythrocyte products compared to donor plasma concentrations, while PAI-1 content was 15-20-fold higher only in plasma-reduced whole-blood and whole-blood. Prestorage leucocyte filtration significantly reduced...Continue Reading

References

Dec 1, 1992·Archives of Surgery·A E Baue
Nov 1, 1992·The Journal of Trauma·T H Edna, T Bjerkeset
Sep 1, 1991·Transfusion·C F HögmanC S Johansson
Apr 18, 1991·The New England Journal of Medicine·P F Weller
Apr 25, 1991·Journal of Immunological Methods·C M ReimertK Bendtzen
Mar 15, 1988·Hospital Practice·G J Gleich
May 1, 1995·The British Journal of Surgery·H J Nielsen
Jul 1, 1994·The British Journal of Surgery·H van GoorR P Bleichrodt
Sep 8, 1994·The New England Journal of Medicine·N M HeddleJ G Kelton
Dec 1, 1993·The British Journal of Surgery·A W BradburyC V Ruckley
Feb 1, 1993·Anaesthesia and Intensive Care·M D Nicholls
Feb 1, 1993·Anaesthesia and Intensive Care·T Gottlieb
Feb 1, 1993·Anaesthesia and Intensive Care·J P Isbister
Feb 1, 1993·Anaesthesia and Intensive Care·M Malouf, A R Glanville
Aug 1, 1996·European Journal of Haematology·L EdvardsenN Brünner

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Citations

Apr 21, 2009·Transfusion·Steve J McFaulJayasree Nath
Jul 22, 1999·European Journal of Haematology·J H HammerH J Nielsen
Mar 14, 2013·Transfusion·Saurabh ZalpuriJaap Jan Zwaginga
Oct 1, 2020·Vox Sanguinis·Tor A HervigUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative
Dec 24, 2004·Current Opinion in Critical Care·Robert N BilkovskiH Matilda Horst
Dec 27, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Rosemary L SparrowMargaret F Veale

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