PMID: 11334211May 4, 2001Paper

Leucodepletion and the interaction of polymorphonuclear cells with endothelium in systemic inflammatory response syndrome

Perfusion
K A BrownDavid F Treacher

Abstract

The abnormal interaction of polymorphonuclear cells (PMNs) with blood vessel walls is considered to underlie the multiple organ failure of systemic inflammatory response syndrome (SIRS). This consideration is supported by the present finding that PMNs from patients with SIRS are activated, as assessed by an increased distribution of cells bearing CD64, enhanced expression of CD11b and decreased expression of CD62L, and are highly adhesive to endothelial monolayers. Passage of SIRS blood through leucodepletion filters in a laboratory-designed extracorporeal circuit resulted in a marked depletion of PMNs. Of the PMNs that remained in the blood, far fewer cells bound to cultured endothelial cells in comparison with PMNs prior to leucofiltration. We propose that leucofiltration of SIRS blood will limit the number of PMNs available for binding to blood vessel walls and, hence, reduce the pathological manifestations associated with this disorder.

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Citations

Aug 26, 2009·The Journal of Physical Chemistry. B·Zackary I ClevelandBastiaan Driehuys
Feb 24, 2009·Journal of Neurotrauma·G Burkhard MackensenDavid S Warner
Feb 10, 2012·Thrombosis and Haemostasis·M V JoglekarG M Arepally
Nov 18, 2008·American Journal of Respiratory Cell and Molecular Biology·Sion M LewisKenneth A Brown
Aug 21, 2008·Journal of Cardiothoracic Surgery·Fellery de LangeG Burkhard Mackensen
Nov 17, 2009·The Journal of Veterinary Medical Science·Kenichi MaedaKatsuaki Takase
Oct 23, 2013·International Immunopharmacology·Sion M LewisK Alun Brown
Jul 11, 2006·Lancet·K A BrownD F Treacher
Dec 23, 2009·Interactive Cardiovascular and Thoracic Surgery·Serdar GunaydinYaman Zorlutuna
Mar 28, 2009·American Journal of Respiratory and Critical Care Medicine·Andrew Conway MorrisA John Simpson
Sep 17, 2003·Anaesthesia and Intensive Care·A TyagiA K Sethi

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