Abstract
The abnormal interaction of polymorphonuclear cells (PMNs) with blood vessel walls is considered to underlie the multiple organ failure of systemic inflammatory response syndrome (SIRS). This consideration is supported by the present finding that PMNs from patients with SIRS are activated, as assessed by an increased distribution of cells bearing CD64, enhanced expression of CD11b and decreased expression of CD62L, and are highly adhesive to endothelial monolayers. Passage of SIRS blood through leucodepletion filters in a laboratory-designed extracorporeal circuit resulted in a marked depletion of PMNs. Of the PMNs that remained in the blood, far fewer cells bound to cultured endothelial cells in comparison with PMNs prior to leucofiltration. We propose that leucofiltration of SIRS blood will limit the number of PMNs available for binding to blood vessel walls and, hence, reduce the pathological manifestations associated with this disorder.
References
Jun 1, 1992·Chest·R C BoneW J Sibbald
May 1, 1992·European Journal of Immunology·A PalecandaM A Jutila
Feb 1, 1992·Current Opinion in Immunology·U S Ryan, R E Worthington
Mar 1, 1992·Immunology Today·G A ZimmermanT M McIntyre
Apr 3, 1992·Cell·R O Hynes
Dec 1, 1990·The Journal of Clinical Investigation·P M GuyreM W Fanger
Jul 1, 1987·The Journal of Clinical Investigation·H H LipowskyD M Katz
Feb 19, 1981·Nature·C V Wedmore, T J Williams
Mar 1, 1995·Intensive Care Medicine·S Fujishima, N Aikawa
Jul 6, 1993·Journal of Immunological Methods·K A BrownC Watson
Sep 1, 1993·Infection·T DarvilleR Jacobs
Feb 1, 1993·Arthritis and Rheumatism·B N Cronstein, G Weissmann
May 1, 1996·World Journal of Surgery·R J Goris
May 1, 1996·World Journal of Surgery·G Schlag, H Redl
Jul 1, 1996·Clinical and Experimental Immunology·A J VoraK A Brown
Jan 1, 1996·Advances in Immunology·N W Lukacs, P A Ward
Feb 20, 1998·Journal of Leukocyte Biology·X Chen, N V Christou
Feb 24, 2001·Perfusion·D B SandersB Yang
Citations
Aug 26, 2009·The Journal of Physical Chemistry. B·Zackary I ClevelandBastiaan Driehuys
Feb 24, 2009·Journal of Neurotrauma·G Burkhard MackensenDavid S Warner
Feb 10, 2012·Thrombosis and Haemostasis·M V JoglekarG M Arepally
Nov 18, 2008·American Journal of Respiratory Cell and Molecular Biology·Sion M LewisKenneth A Brown
Aug 21, 2008·Journal of Cardiothoracic Surgery·Fellery de LangeG Burkhard Mackensen
Nov 17, 2009·The Journal of Veterinary Medical Science·Kenichi MaedaKatsuaki Takase
Oct 23, 2013·International Immunopharmacology·Sion M LewisK Alun Brown
Jul 11, 2006·Lancet·K A BrownD F Treacher
Jun 10, 2004·The Journal of Trauma·Hiroshi OguraHisashi Sugimoto
Dec 19, 2001·Anesthesiology·B J HindmanJ E Brian
Dec 19, 2001·Anesthesiology·G B MackensenH P Grocott
Feb 28, 2003·Anesthesiology·Daqing MaHilary P Grocott
Dec 23, 2009·Interactive Cardiovascular and Thoracic Surgery·Serdar GunaydinYaman Zorlutuna
Apr 14, 2010·Shock·Tuneyasu KumagaiHiroshi Noguchi
Mar 28, 2009·American Journal of Respiratory and Critical Care Medicine·Andrew Conway MorrisA John Simpson
May 29, 2002·Anesthesia and Analgesia·Yukie SatoHilary P Grocott
Sep 17, 2003·Anaesthesia and Intensive Care·A TyagiA K Sethi
Dec 24, 2005·Alternatives to Laboratory Animals : ATLA·Chris LangleyKarl Wooldridge