Leucosulfakinin, a sulfated insect neuropeptide with homology to gastrin and cholecystokinin

Science
Ronald J NachmanN Ling

Abstract

A sulfated, myotropic neuropeptide termed leucosulfakinin (Glu-Gln-Phe-Glu-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-NH2) was isolated from head extracts of the cockroach Leucophaea maderae. The peptide exhibits sequence homology with the hormonally active portion of the vertebrate hormones human gastrin II and cholecystokinin, suggesting that these peptides are evolutionarily related. Six of the 11 amino acid residues (55 percent) are identical to those in gastrin II. In addition, the intestinal myotropic action of leucosulfakinin is analogous to that of gastrin.

References

Dec 19, 1970·Nature·M I Grossman
Jan 14, 1970·Journal of the American Chemical Society·M A OndettiN Williams
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R M ScarboroughD A Schooley
Jan 1, 1983·Progress in Neurobiology·J A Deutsch

❮ Previous
Next ❯

Citations

Jan 1, 1993·Archives of Insect Biochemistry and Physiology·R J NachmanW F Haddon
Jun 1, 1989·Die Naturwissenschaften·H Penzlin
Mar 17, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Pawel MarciniakGrzegorz Rosinski
Oct 31, 2008·Cell and Tissue Research·Jan A VeenstraAzza Sellami
Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Jan 1, 1996·Pharmacology & Therapeutics·R H Osborne
May 1, 1993·Peptides·C Cowden, A O Stretton
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A De Loof, L Schoofs
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B J CookR J Nachman
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B J CookR J Nachman
Jun 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R J Walker
Jun 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A FónagyA De Loof
Sep 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A FónagyA De Loof
Dec 1, 1993·Insect Biochemistry and Molecular Biology·L SchoofsA De Loof
Jun 14, 2000·Journal of Insect Physiology·Z WeiL Schoofs
Apr 11, 2003·Regulatory Peptides·David A KeireJoseph R Reeve
Apr 16, 1998·Regulatory Peptides·C H Hoyle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.