PMID: 9190039Feb 1, 1997Paper

Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome

Seminars in Perinatology
A ZipurskyJ Doyle

Abstract

Approximately 10% of newborn infants with Down Syndrome develop a form of megakaryoblastic leukemia which usually disappears spontaneously during the first months of life. The evidence that this "Transient Leukemia" is truly leukemia includes the following: it is clonal proliferation, it can be fatal and tissue infiltration of leukemic cells occurs. Also in approximately 25% of cases that recover, Acute Megakaryoblastic Leukemia will develop in the first four years of life, which, if not treated, is fatal. Evidence regarding the megakaryoblastic nature of the leukemic cells is presented as well as a description of the lethal forms of the disease. The study of Transient Leukemia is of considerable importance because it can provide insight into both the nature of leukemia and its relation to trisomy 21.

Citations

Apr 1, 1999·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S Siva, J Smoleniec
Jan 18, 2005·Journal of Pediatric Hematology/oncology·Isis Quezado MagalhãesMaria S Pombo-de-Oliveira
Oct 19, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Natalia DixonSherri Zimmerman
Mar 26, 2008·Pediatric Hematology and Oncology·Rathika D ShenoyYusuf Kumble
Jan 16, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Prabhu ManivannanDebdatta Basu
Oct 26, 2000·The Journal of Obstetrics and Gynaecology Research·C HirashimaI Sato
Mar 21, 2002·Journal of Pediatric Hematology/oncology·Shawn E HoltAlvin Zipursky
Mar 22, 2003·British Journal of Haematology·Alvin Zipursky
Jun 23, 2011·International Journal of Laboratory Hematology·D-W KimD-W Ryang
Sep 13, 2012·British Journal of Haematology·Alan S Gamis, Franklin O Smith
Jun 19, 2015·Clinical Pediatrics·Stephanie L SantoroRobert J Hopkin
Aug 15, 2020·Scientific Reports·David de Gonzalo-CalvoMireia Tondo
Jul 19, 2020·American Journal of Medical Genetics. Part a·Mireya Orozco-VelaJorge Román Corona-Rivera
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M SmrcekU Gembruch
Mar 21, 2002·Journal of Pediatric Hematology/oncology·Jeffrey W Taub, Yaddanapudi Ravindranath
Jun 12, 2004·Blood·Laurent GarderetUNKNOWN Acute Leukemia Working Party and Pediatric Working Party of the European Group for Blood and Marrow Transplantation
Jul 2, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M OgawaT Tanaka
May 6, 2004·Journal of Pediatric Hematology/oncology·Anwar Sheikha
Sep 22, 2005·British Journal of Haematology·David K H Webb
Mar 11, 2003·Prenatal Diagnosis·A AzancotJ F Oury
Nov 21, 2013·European Journal of Pediatrics·Laurence RozenAnne Demulder
Jun 17, 2004·British Journal of Haematology·Shai Izraeli
Jul 8, 2011·Cytogenetic and Genome Research·R Sukenik-HalevyA Amiel
Nov 21, 2007·British Journal of Community Nursing·Catherine Hayes
Feb 3, 2011·Indian Journal of Pediatrics·Ming-Horng TsaiHsuan-Rong Huang
Jan 11, 2016·Paediatric Anaesthesia·Amy Feldman LewandaMarshall Summar
Dec 30, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Kenichiro Watanabe
Apr 18, 2001·Journal of Pediatric Hematology/oncology·J W Taub
Oct 9, 2003·Annals of the ICRP·Roger Cox, Christian Streffer

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