PMID: 6983693Nov 1, 1982Paper

Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line

Proceedings of the National Academy of Sciences of the United States of America
C H Uittenbogaart, J L Fahey

Abstract

A growth factor was found in the supernatants of MOLT-4f, a cell line derived from acute T lymphoblastic leukemia. This factor, which we designated leukemia-derived growth factor from MOLT-4f (LDGF-M4), is different from interleukin 2. LDGF-M4 has features of a polypeptide with a molecular weight in the range of 5,000-15,000, as indicated by gel diffusion chromatography. LDGF-M4 does stimulate MOLT-4f and at least two other T cell lines that do not respond to interleukin 2. Because MOLT-4f cells produce and respond to LDGF-M4, this factor may contribute to the independence of MOLT-4f and related T leukemia cell lines.

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J E de Larco, G J Todaro
Jan 1, 1976·Annual Review of Biochemistry·D Gospodarowicz, J S Moran
Feb 1, 1972·The Journal of Experimental Medicine·D G TubergenR A Lerner
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Nov 1, 1981·The Journal of Experimental Medicine·J E GootenbergR C Gallo

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Citations

Apr 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A MiharaN Fujiyoshi
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E F HaysC H Uittenbogaart
May 1, 1984·The Journal of Experimental Medicine·J GordonN C Hughes-Jones
Jul 12, 1984·Nature·J GordonN C Hughes-Jones
Feb 15, 1986·International Journal of Cancer. Journal International Du Cancer·C KosmatopoulosV Georgoulias

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