PMID: 18406307Apr 15, 2008Paper

Leukemia in children treated with growth hormone

Trends in Endocrinology and Metabolism : TEM
S L Blethen

Abstract

An association between treatment with growth hormone (GH) and the development of leukemia was described in 1988. This perceived association is best explained by the fact that there are more children with GH deficiency (GHD) with risk factors predisposing them to leukemia than in the general population. These factors include previous cancers and their treatment, as well as co-existing conditions such as Down, Bloom and Fanconi syndromes. Examination of large databases of GH-treated individuals shows that GH-treated patients without these risk factors do not have an increased incidence of leukemia.

References

Nov 1, 1981·British Journal of Haematology·F BreatnachM F Greaves
May 1, 1995·European Journal of Pediatrics·M KubotaS Watanabe
May 1, 1995·The Journal of Pediatrics·R RapaportG P Redmond
Dec 15, 1993·JAMA : the Journal of the American Medical Association·J E FradkinL L Robison
Jan 1, 1993·The Journal of Pediatric Endocrinology·S WatanabeA Komiyama
Mar 1, 1993·The Journal of Clinical Endocrinology and Metabolism·S L BlethenA Johanson
Mar 21, 1996·The New England Journal of Medicine·S BhatiaA T Meadows
Jun 1, 1997·Annals of Hematology·S GiesbertE R Panzer-Grümayer
Jul 1, 1997·The Journal of Pediatrics·D B AllenS L Blethen
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May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FordM Greaves

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Citations

Jan 29, 2010·Acta Paediatrica·Å MyrelidG Annerén
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Angela M Spinola e Castro, Gil Guerra-Júnior

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